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• W2130556988 endingPage "6147" @default.
• W2130556988 startingPage "6141" @default.
• W2130556988 abstract "The induction of the SOS response by H2O2 was measured in Escherichia coli by means of a sfiA::lacZ operon fusion. The effects of mutations in genes involved in DNA repair or DNA metabolism on the SOS response were investigated. We found that in an uvrA mutant, H2O2 induced the SOS response at lower concentrations than in the uvr+ parent strain, indicating that some lesions induced by H2O2 may be repaired by the uvrABC-dependent excision repair system. A nth mutation, yielding deficiency in thymine glycol DNA glycosylase, had no detectable effect on SOS induction, indicating that thymine glycol, a DNA lesion expected to be induced by H2O2, does not participate detectably in the induction of the SOS response by this chemical under our conditions. H2O2 still induced the SOS response in a dnaC(Ts) uvrA double mutant under conditions in which no DNA replication proceeds, suggesting that this chemical induces DNA strand breaks. Induction of the SOS response by H2O2 was also assayed in various mutants affected in genes suspected to be important for protection against oxidative stress. Mutations in the catalase genes, katE and katG, had only minor effects. However, in an oxyR deletion mutant, in which the adaptative response to H2O2 does not occur, SOS induction occurred at much lower H2O2 concentrations than in the oxyR+ parent strain. These results indicate that some enzymes regulated by the oxyR gene are, under our conditions, more important than catalase for protection against the H2O2-induced DNA damages which trigger the SOS response." @default.
• W2130556988 created "2016-06-24" @default.
• W2130556988 creator A5003935549 @default.
• W2130556988 creator A5032042682 @default.
• W2130556988 creator A5077054500 @default.
• W2130556988 date "1989-11-01" @default.
• W2130556988 modified "2023-10-12" @default.
• W2130556988 title "Induction of the SOS response by hydrogen peroxide in various Escherichia coli mutants with altered protection against oxidative DNA damage" @default.
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• W2130556988 doi "https://doi.org/10.1128/jb.171.11.6141-6147.1989" @default.
• W2130556988 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/210482" @default.
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