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- W2130565528 abstract "Mammalian mRNAs are generated by complex and coordinated biogenesis pathways and acquire 5'-end m(7)G caps that play fundamental roles in processing and translation. Here we show that several selenoprotein mRNAs are not recognized efficiently by translation initiation factor eIF4E because they bear a hypermethylated cap. This cap modification is acquired via a 5'-end maturation pathway similar to that of the small nucle(ol)ar RNAs (sn- and snoRNAs). Our findings also establish that the trimethylguanosine synthase 1 (Tgs1) interacts with selenoprotein mRNAs for cap hypermethylation and that assembly chaperones and core proteins devoted to sn- and snoRNP maturation contribute to recruiting Tgs1 to selenoprotein mRNPs. We further demonstrate that the hypermethylated-capped selenoprotein mRNAs localize to the cytoplasm, are associated with polysomes and thus translated. Moreover, we found that the activity of Tgs1, but not of eIF4E, is required for the synthesis of the GPx1 selenoprotein in vivo." @default.
- W2130565528 created "2016-06-24" @default.
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- W2130565528 date "2014-07-10" @default.
- W2130565528 modified "2023-10-18" @default.
- W2130565528 title "Hypermethylated-capped selenoprotein mRNAs in mammals" @default.
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- W2130565528 cites W1898843877 @default.
- W2130565528 cites W1969664706 @default.
- W2130565528 cites W1971402937 @default.
- W2130565528 cites W1976019518 @default.
- W2130565528 cites W1977540067 @default.
- W2130565528 cites W1978098648 @default.
- W2130565528 cites W1981649873 @default.
- W2130565528 cites W1987759561 @default.
- W2130565528 cites W1989000331 @default.
- W2130565528 cites W1989646488 @default.
- W2130565528 cites W1990393476 @default.
- W2130565528 cites W1991394753 @default.
- W2130565528 cites W1993243592 @default.
- W2130565528 cites W1993893473 @default.
- W2130565528 cites W2003018523 @default.
- W2130565528 cites W2005105190 @default.
- W2130565528 cites W2005404486 @default.
- W2130565528 cites W2006977511 @default.
- W2130565528 cites W2010116656 @default.
- W2130565528 cites W2011181458 @default.
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- W2130565528 cites W2033704741 @default.
- W2130565528 cites W2034761258 @default.
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- W2130565528 cites W2039867172 @default.
- W2130565528 cites W2040174498 @default.
- W2130565528 cites W2043059870 @default.
- W2130565528 cites W2046828533 @default.
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- W2130565528 cites W2066018734 @default.
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- W2130565528 cites W2078092202 @default.
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- W2130565528 doi "https://doi.org/10.1093/nar/gku580" @default.
- W2130565528 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4117793" @default.
- W2130565528 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25013170" @default.
- W2130565528 hasPublicationYear "2014" @default.
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