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• W2130581610 startingPage "33" @default.
• W2130581610 abstract "The dentate gyrus of the hippocampus is one of the most prominent regions in the postnatal mammalian brain where neurogenesis continues throughout life. There is tremendous speculation regarding the potential implications of adult hippocampal neurogenesis, though it remains unclear to what extent this ability becomes attenuated during normal aging, and what genetic changes in the progenitor population ensue over time. Using defined elements of the nestin promoter, we developed a transgenic mouse that reliably labels neural stem and early progenitors with green fluorescent protein (GFP). Using a combination of immunohistochemical and flow cytometry techniques, we characterized the progenitor cells within the dentate gyrus and created a developmental profile from postnatal day 7 (P7) until 6 months of age. In addition, we demonstrate that the proliferative potential of these progenitors is controlled at least in part by cell-autonomous cues. Finally, to identify what may underlie these differences, we performed stem cell-specific microarrays on GFP-expressing sorted cells from isolated P7 and postnatal day 28 (P28) dentate gyrus. We identified several differentially expressed genes that may underlie the functional differences that we observe in neurosphere assays from sorted cells and differentiation assays at these different ages. These data suggest that neural progenitors from the dentate gyrus are differentially regulated by cell-autonomous factors that change over time." @default.
• W2130581610 created "2016-06-24" @default.
• W2130581610 creator A5000571244 @default.
• W2130581610 creator A5033777911 @default.
• W2130581610 creator A5067468186 @default.
• W2130581610 date "2010-12-23" @default.
• W2130581610 modified "2023-09-24" @default.
• W2130581610 title "Developmental profiling of postnatal dentate gyrus progenitors provides evidence for dynamic cell-autonomous regulation" @default.
• W2130581610 cites W1524059733 @default.
• W2130581610 cites W1589249341 @default.
• W2130581610 cites W1595834812 @default.
• W2130581610 cites W1746095826 @default.
• W2130581610 cites W1764972970 @default.
• W2130581610 cites W1913938270 @default.
• W2130581610 cites W1962404374 @default.
• W2130581610 cites W1964306102 @default.
• W2130581610 cites W1964840560 @default.
• W2130581610 cites W1965976131 @default.
• W2130581610 cites W1967095650 @default.
• W2130581610 cites W1972830850 @default.
• W2130581610 cites W1979553110 @default.
• W2130581610 cites W1980499453 @default.
• W2130581610 cites W1984637659 @default.
• W2130581610 cites W1985502949 @default.
• W2130581610 cites W1990923337 @default.
• W2130581610 cites W1990962744 @default.
• W2130581610 cites W1994042895 @default.
• W2130581610 cites W1999321510 @default.
• W2130581610 cites W2002161951 @default.
• W2130581610 cites W2003410399 @default.
• W2130581610 cites W2005981572 @default.
• W2130581610 cites W2017452389 @default.
• W2130581610 cites W2018354332 @default.
• W2130581610 cites W2020541351 @default.
• W2130581610 cites W2022600603 @default.
• W2130581610 cites W2023060626 @default.
• W2130581610 cites W2026398288 @default.
• W2130581610 cites W2026904817 @default.
• W2130581610 cites W2027355910 @default.
• W2130581610 cites W2028574954 @default.
• W2130581610 cites W2031698314 @default.
• W2130581610 cites W2032895185 @default.
• W2130581610 cites W2034372853 @default.
• W2130581610 cites W2035250926 @default.
• W2130581610 cites W2037914328 @default.
• W2130581610 cites W2040786733 @default.
• W2130581610 cites W2042154782 @default.
• W2130581610 cites W2047245618 @default.
• W2130581610 cites W2048809344 @default.
• W2130581610 cites W2050564403 @default.
• W2130581610 cites W2053032855 @default.
• W2130581610 cites W2056963133 @default.
• W2130581610 cites W2060112651 @default.
• W2130581610 cites W2062045688 @default.
• W2130581610 cites W2065564965 @default.
• W2130581610 cites W2068113532 @default.
• W2130581610 cites W2069338913 @default.
• W2130581610 cites W2072895093 @default.
• W2130581610 cites W2076137498 @default.
• W2130581610 cites W2077110494 @default.
• W2130581610 cites W2077769816 @default.
• W2130581610 cites W2079156156 @default.
• W2130581610 cites W2082469825 @default.
• W2130581610 cites W2082574627 @default.
• W2130581610 cites W2084253372 @default.
• W2130581610 cites W2087025782 @default.
• W2130581610 cites W2088745158 @default.
• W2130581610 cites W2089425745 @default.
• W2130581610 cites W2089426706 @default.
• W2130581610 cites W2100192772 @default.
• W2130581610 cites W2104557195 @default.
• W2130581610 cites W2105086774 @default.
• W2130581610 cites W2108340830 @default.
• W2130581610 cites W2109542855 @default.
• W2130581610 cites W2109694255 @default.
• W2130581610 cites W2116447221 @default.
• W2130581610 cites W2117370259 @default.
• W2130581610 cites W2126335823 @default.
• W2130581610 cites W2128744963 @default.
• W2130581610 cites W2132565242 @default.
• W2130581610 cites W2133619319 @default.
• W2130581610 cites W2135758711 @default.
• W2130581610 cites W2139481908 @default.
• W2130581610 cites W2142525943 @default.
• W2130581610 cites W2143351375 @default.
• W2130581610 cites W2145235967 @default.
• W2130581610 cites W2145925994 @default.
• W2130581610 cites W2146045918 @default.
• W2130581610 cites W2149146453 @default.
• W2130581610 cites W2152373356 @default.
• W2130581610 cites W2157252680 @default.
• W2130581610 cites W2158496649 @default.
• W2130581610 cites W2159460039 @default.
• W2130581610 cites W2160280025 @default.
• W2130581610 cites W2160644313 @default.
• W2130581610 cites W2162908902 @default.
• W2130581610 cites W2163449769 @default.
• W2130581610 cites W2164061655 @default.

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