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• W2130594577 startingPage "1721" @default.
• W2130594577 abstract "The serine/threonine kinase protein kinase B (PKB)/Akt mediates cell survival in a variety of systems. We have generated transgenic mice expressing a constitutively active form of PKB (gag-PKB) to examine the effects of PKB activity on T lymphocyte survival. Thymocytes and mature T cells overexpressing gag-PKB displayed increased active PKB, enhanced viability in culture, and resistance to a variety of apoptotic stimuli. PKB activity prolonged the survival of CD4+CD8+ double positive (DP) thymocytes in fetal thymic organ culture, but was unable to prevent antigen-induced clonal deletion of thymocytes expressing the major histocompatibility complex class I–restricted P14 T cell receptor (TCR). In mature T lymphocytes, PKB can be activated in response to TCR stimulation, and peptide-antigen–specific proliferation is enhanced in T cells expressing the gag-PKB transgene. Both thymocytes and T cells overexpressing gag-PKB displayed elevated levels of the antiapoptotic molecule Bcl-XL. In addition, the activation of peripheral T cells led to enhanced nuclear factor (NF)-κB activation via accelerated degradation of the NF-κB inhibitory protein IκBα. Our data highlight a physiological role for PKB in promoting survival of DP thymocytes and mature T cells, and provide evidence for the direct association of three major survival molecules (PKB, Bcl-XL, and NF-κB) in vivo in T lymphocytes." @default.
• W2130594577 created "2016-06-24" @default.
• W2130594577 creator A5004810465 @default.
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• W2130594577 creator A5043927370 @default.
• W2130594577 creator A5045167813 @default.
• W2130594577 creator A5060222946 @default.
• W2130594577 date "2000-05-15" @default.
• W2130594577 modified "2023-10-16" @default.
• W2130594577 title "Protein Kinase B Regulates T Lymphocyte Survival, Nuclear Factor κb Activation, and Bcl-XL Levels in Vivo" @default.
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• W2130594577 doi "https://doi.org/10.1084/jem.191.10.1721" @default.
• W2130594577 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2193154" @default.
• W2130594577 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10811865" @default.
• W2130594577 hasPublicationYear "2000" @default.
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