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• W2130595939 abstract "Modulation of sympathetic tone may contribute to statin-mediated reduction in sudden cardiac death. We examined the effect of simvastatin on heart rate variability (HRV) in patients with non-ischemic dilated cardiomyopathy to evaluate for an antisympathetic effect of statins independent of anti-ischemic properties. The study was a prospective, open-label, self-controlled trial. Frequency domain analysis of HRV was assessed in 25 patients with non-ischemic dilated cardiomyopathy at baseline and after a 6-week course of simvastatin. The primary end point was the change in 5-minute sitting total spectral power (TSP) as a composite measurement of autonomic nervous system modulation. Secondary end points included the change in respiratory frequency area (RFa) with deep breathing (parasympathetic stress) and in low-frequency area (LFa) with Valsalva (sympathetic stress). Simvastatin had no effect on 5-minute sitting TSP (baseline 1932 ± 1165 vs posttreatment 2570 ± 1877 square milliseconds, P = .770), RFa with deep breathing (baseline 19 ± 7 vs posttreatment 14 ± 4 [beat/min]2, P = .31), or LFa with Valsalva (baseline 26 ± 6 vs posttreatment 32 ± 8 [beat/min]2, P = .342). Bivariate analysis demonstrated no correlation between low-density lipoprotein (LDL) change and change in TSP or RFa, but did demonstrate an inverse relationship between change in LDL and change in LFa with Valsalva stress (r = −0.45 and P = .041). Although simvastatin did not change baseline HRV, a modest relationship exists between the extent of LDL reduction and sympathetic responsiveness to stress. (Am Heart J 2005;150: 478-83.)" @default.
• W2130595939 created "2016-06-24" @default.
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• W2130595939 date "2005-09-01" @default.
• W2130595939 modified "2023-10-16" @default.
• W2130595939 title "A prospective evaluation of the effect of simvastatin on heart rate variability in non-ischemic cardiomyopathy" @default.
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• W2130595939 doi "https://doi.org/10.1016/j.ahj.2004.10.031" @default.
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