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• W2130605760 abstract "Plant saponins exhibit numerous pharmacological characteristics desirable for long term hyperlipidemic therapy through their cholesterol binding capacity due to the formation of liposomes/phytosomes which ultimately decreases the gastrointestinal absorption of cholesterol. This may result in the reduction of the blood plasma cholesterol levels; hence, mitigating cardiovascular and atherosclerotic problems that are associated with elevated plasma cholesterol concentrations. In this study, we reported for the first time a potential method of synthesizing phytosomes/liposomes from two medicinal plants Pentanisia prunelloides (Rubiaceae) and Elephantorrhiza elephantina (Fabaceae) saponin extracts and fractions using α-phosphotidycholine and cholesterol. This was done to explore the possibility of cholesterol binding capacity of fractions and extracts of the two medicinal plants as a justification of their application by traditional healers in managing body weight as well as averting hyperlipidemia and atherosclerosis. Spherical nanoparticles/phytosomes/liposomes were clearly identified in the TEM images with particle sizes ranging between tens and hundreds of nanometers. The zeta potential of the nanoparticles fell between -5 and +5 mV indicating that they have a high potential for aggregation; hence, making it relatively very difficult for the complexed cholesterol molecules to permeate the microscopic pores in the alimentary tract.   Key words: Frontier transmission infra-red (FTIR), liposomes, adjuvants, zeta-potential, α-phosphotidycholine. &nbsp" @default.
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• W2130605760 date "2014-03-19" @default.
• W2130605760 modified "2023-10-16" @default.
• W2130605760 title "Synthesis of liposomes using -phosphotidycholine and metabolites obtained from Elephantorrhiza elephantina and Pentanisia prunelloides" @default.
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• W2130605760 doi "https://doi.org/10.5897/ajb2013.13330" @default.
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