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• W2130606388 abstract "G-protein-coupled estrogen receptor (GPER/GPR30) was reported to bind 17β-estradiol (E2), tamoxifen, and ICI 182,780 (fulvestrant) and promotes activation of epidermal growth factor receptor (EGFR)-mediated signaling in breast, endometrial and thyroid cancer cells. Although lung adenocarcinomas express estrogen receptors α and β (ERα and ERβ), the expression of GPER in lung cancer has not been investigated. The purpose of this study was to examine the expression of GPER in lung cancer. The expression patterns of GPER in various lung cancer lines and lung tumors were investigated using standard quantitative real time PCR (at mRNA levels), Western blot and immunohistochemistry (IHC) methods (at protein levels). The expression of GPER was scored and the pairwise comparisons (cancer vs adjacent tissues as well as cancer vs normal lung tissues) were performed. Analysis by real-time PCR and Western blotting revealed a significantly higher expression of GPER at both mRNA and protein levels in human non small cell lung cancer cell (NSCLC) lines relative to immortalized normal lung bronchial epithelial cells (HBECs). The virally immortalized human small airway epithelial cell line HPL1D showed higher expression than HBECs and similar expression to NSCLC cells. Immunohistochemical analysis of tissue sections of murine lung adenomas as well as human lung adenocarcinomas, squamous cell carcinomas and non-small cell lung carcinomas showed consistently higher expression of GPER in the tumor relative to the surrounding non-tumor tissue. The results from this study demonstrate increased GPER expression in lung cancer cells and tumors compared to normal lung. Further evaluation of the function and regulation of GPER will be necessary to determine if GPER is a marker of lung cancer progression." @default.
• W2130606388 created "2016-06-24" @default.
• W2130606388 creator A5030651603 @default.
• W2130606388 creator A5046637632 @default.
• W2130606388 creator A5058082625 @default.
• W2130606388 creator A5070981762 @default.
• W2130606388 date "2012-12-01" @default.
• W2130606388 modified "2023-10-14" @default.
• W2130606388 title "Enhanced expression of G-protein coupled estrogen receptor (GPER/GPR30) in lung cancer" @default.
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• W2130606388 doi "https://doi.org/10.1186/1471-2407-12-624" @default.
• W2130606388 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3557142" @default.
• W2130606388 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23273253" @default.
• W2130606388 hasPublicationYear "2012" @default.
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