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- W2130607871 abstract "This letter is in response to comments by Pauly et al. regarding the findings from the human exposure study with carbon filter cigarettes (Sarkar et al., 2008). The study being commented upon is based on a series of clinical studies, carried out in confined as well as ambulatory settings, testing the effect of carbon filtration on smoke exposure. These studies have demonstrated that activated carbon results in a significant reduction in the biomarkers of gas vapor phase smoke constituents. However, as indicated in our paper, the lack of favorable changes in the biomarkers of inflammation, oxidative stress, and cardiovascular risk (based on an exploratory analysis) calls into question the clinical relevance of these exposure reductions. Therefore, the impact of reductions in the gas vapor smoke constituents on smoking-related disease still needs to be established. In our investigations, we used specific prototype cigarettes in order to systematically compare the relative changes in exposure due to carbon, by designing the cigarettes to be identical except for the inclusion of carbon. This would not have been possible with commercial cigarettes due to variations in cigarette design parameters, making interpretation of the results difficult. Inclusion of reference standards or commercial cigarettes would have served no additional purpose in making the relative comparisons. Furthermore, as is often the case for new innovations, early prototypical versions are extensively tested before a commercial version is made available in the market. Therefore, this test was of a predecessor version of the Marlboro Ultra Smooth, before the commercial cigarettes were placed in the market." @default.
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- W2130607871 date "2009-07-27" @default.
- W2130607871 modified "2023-09-25" @default.
- W2130607871 title "Human exposure studies evaluating carbon filtered cigarettes: Response to Pauly et al." @default.
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- W2130607871 doi "https://doi.org/10.1093/ntr/ntp121" @default.
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