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- W2130609570 abstract "Anticoagulation with Oral Vitamin- K-Antagonists in Risk Patients: Clinical and Economical Benefit of an Adequate Preven- tion. Background: Long-term anticoagulation with oral vitamin-K-antagonists (OVKA) in patients with risk fac- tors (atrial fibrillation (AF), mechanical heart valve re- placement (MVR)) represents an effective method in the primary and secondary prevention of thromboem- bolic complications. However, due to the fact that these drugs have the potential to induce severe haemor- rhagic events, the use of OVKA requires close monitor- ing of the anticoagulation level. The aim of this phar- maco-economic analysis was to assess the efficacy of OVKA compared to acetylic salicylic acid (ASA) as well as the efficiency depending on the method of monitor- ing (self-measurement vs. ambulatory monitoring). Methods: A pharmaco-economic analysis was per- formed using two Markov models to assess the out- comes of using OVKA and ASA in patients with diag- nosed AF and the method of monitoring in patients with MVR. The models included the clinical complica- tions of bleeding, stroke and mortality as well as treat- ment, monitoring and complication related costs, which were derived from published sources. For both sce- narios, the cumulated ten-year mortality, total costs and life years gained were calculated for different risk" @default.
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- W2130609570 date "2006-10-03" @default.
- W2130609570 modified "2023-09-23" @default.
- W2130609570 title "Antikoagulation mit oralen Vitamin-K-Antagonisten bei Risikopatienten: klinischer und wirtschaftlicher Nutzen einer adäquaten Prävention" @default.
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