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- W2130652452 abstract "AbstractThe compaction properties of an investigational drug are studied by the use of a compaction simulator. The effects of punch velocity over the range of 30-640 mm−1 on the compaction properties of the pure drug and a variety of formulas incorporating a high dose of the active compound have been investigated. The data were analyzed by applying the Heckel equation. The pure drug was found to have a high yield pressure at a relatively low punch velocity of 31 mm−1. As the punch velocity was increased there was a decrease in crushing strength, primarily as a result of increasing yield pressure. These findings indicate that the pure drug predominantly consolidated by fragmentation and elastic deformation, with a slow plastically deforming component. The information obtained on the consolidation mechanism of the pure drug and, subsequently, on model formulas were instrumental in the design and selection of a robust formula and granulation process. The advantages of conducting dosage form design and charac..." @default.
- W2130652452 created "2016-06-24" @default.
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- W2130652452 date "1996-01-01" @default.
- W2130652452 modified "2023-09-23" @default.
- W2130652452 title "Application of a Compaction Simulator to the Design of a High-Dose Tablet Formulation. Part I" @default.
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- W2130652452 doi "https://doi.org/10.3109/03639049609065927" @default.
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