FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2130652971> ?p ?o ?g. }

• W2130652971 endingPage "49" @default.
• W2130652971 startingPage "39" @default.
• W2130652971 abstract "The mechanisms underlying induction of immune dysregulation and chronic fungal infection by a transient tumor necrosis factor alpha (TNF-alpha) deficiency remain to be defined. The objective of our studies was to determine the potential contribution of neutropenia and immature dendritic cells to the immune deviation. Administration of an anti-TNF-alpha monoclonal antibody at day 0 neutralized TNF-alpha only during the first week of a pulmonary Cryptococcus neoformans infection. Transient neutralization of TNF-alpha resulted in transient depression of interleukin-12 (IL-12), monocyte chemotactic protein 1 (MCP-1), and gamma interferon (IFN-gamma) production but permanently impaired long-term clearance of the infection from the lungs even after the levels of these cytokines increased and a vigorous inflammatory response developed. Early neutrophil recruitment was defective in the absence of TNF-alpha. However, as demonstrated by neutrophil depletion studies, this did not account for the decrease in IL-12 and IFN-gamma levels and did not play a role in establishing chronic pulmonary cryptococcal infection. Transient TNF-alpha neutralization also produced a deficiency in CD11c(+) MHC II(+) cells and IL-12 in the lymph nodes, potentially implicating a defect in mature dendritic cell trafficking. Transfer of cryptococcal antigen-pulsed immature dendritic cells into naive mice prior to intratracheal challenge resulted in the development of a nonprotective immune response to C. neoformans that was similar to that observed in anti-TNF-alpha-treated mice (increased IL-4, IL-5, and IL-10 levels, pulmonary eosinophilia, and decreased clearance). Thus, stimulation of an antifungal response by immature dendritic cells can result in an immune deviation similar to that produced by transient TNF-alpha deficiency, identifying a new mechanism by which a chronic fungal infection can occur in an immunocompetent host." @default.
• W2130652971 created "2016-06-24" @default.
• W2130652971 creator A5012661599 @default.
• W2130652971 creator A5013008945 @default.
• W2130652971 creator A5040601075 @default.
• W2130652971 creator A5042199822 @default.
• W2130652971 creator A5051166767 @default.
• W2130652971 creator A5083690478 @default.
• W2130652971 date "2005-01-01" @default.
• W2130652971 modified "2023-10-09" @default.
• W2130652971 title "Transient Neutralization of Tumor Necrosis Factor Alpha Can Produce a Chronic Fungal Infection in an Immunocompetent Host: Potential Role of Immature Dendritic Cells" @default.
• W2130652971 cites W1555578877 @default.
• W2130652971 cites W1556118461 @default.
• W2130652971 cites W1566927595 @default.
• W2130652971 cites W1588791132 @default.
• W2130652971 cites W1661544713 @default.
• W2130652971 cites W180072684 @default.
• W2130652971 cites W1802820735 @default.
• W2130652971 cites W1948394619 @default.
• W2130652971 cites W1958291016 @default.
• W2130652971 cites W1968855023 @default.
• W2130652971 cites W1969013826 @default.
• W2130652971 cites W1998247210 @default.
• W2130652971 cites W2017324825 @default.
• W2130652971 cites W2024612551 @default.
• W2130652971 cites W2029394645 @default.
• W2130652971 cites W2036767465 @default.
• W2130652971 cites W2039639303 @default.
• W2130652971 cites W2041200595 @default.
• W2130652971 cites W2043796257 @default.
• W2130652971 cites W2066013154 @default.
• W2130652971 cites W2071482126 @default.
• W2130652971 cites W2074025721 @default.
• W2130652971 cites W2075836508 @default.
• W2130652971 cites W2097884283 @default.
• W2130652971 cites W2100488509 @default.
• W2130652971 cites W2102689053 @default.
• W2130652971 cites W2107649276 @default.
• W2130652971 cites W2109586835 @default.
• W2130652971 cites W2111220263 @default.
• W2130652971 cites W2112957913 @default.
• W2130652971 cites W2114328256 @default.
• W2130652971 cites W2119182059 @default.
• W2130652971 cites W2123655574 @default.
• W2130652971 cites W2127537536 @default.
• W2130652971 cites W2128098084 @default.
• W2130652971 cites W2131563799 @default.
• W2130652971 cites W2131652664 @default.
• W2130652971 cites W2131818384 @default.
• W2130652971 cites W21346515 @default.
• W2130652971 cites W2138961639 @default.
• W2130652971 cites W2139205960 @default.
• W2130652971 cites W2149057253 @default.
• W2130652971 cites W2151277498 @default.
• W2130652971 cites W2155935143 @default.
• W2130652971 cites W2158038433 @default.
• W2130652971 cites W2158372551 @default.
• W2130652971 cites W2162373011 @default.
• W2130652971 cites W2162817739 @default.
• W2130652971 cites W2167297241 @default.
• W2130652971 cites W2170170457 @default.
• W2130652971 cites W2297408211 @default.
• W2130652971 cites W4210875411 @default.
• W2130652971 cites W4313335828 @default.
• W2130652971 cites W4313342450 @default.
• W2130652971 cites W4313347792 @default.
• W2130652971 cites W953351818 @default.
• W2130652971 doi "https://doi.org/10.1128/iai.73.1.39-49.2005" @default.
• W2130652971 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/538928" @default.
• W2130652971 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15618139" @default.
• W2130652971 hasPublicationYear "2005" @default.
• W2130652971 type Work @default.
• W2130652971 sameAs 2130652971 @default.
• W2130652971 citedByCount "64" @default.
• W2130652971 countsByYear W21306529712012 @default.
• W2130652971 countsByYear W21306529712013 @default.
• W2130652971 countsByYear W21306529712014 @default.
• W2130652971 countsByYear W21306529712015 @default.
• W2130652971 countsByYear W21306529712016 @default.
• W2130652971 countsByYear W21306529712017 @default.
• W2130652971 countsByYear W21306529712018 @default.
• W2130652971 countsByYear W21306529712019 @default.
• W2130652971 countsByYear W21306529712022 @default.
• W2130652971 countsByYear W21306529712023 @default.
• W2130652971 crossrefType "journal-article" @default.
• W2130652971 hasAuthorship W2130652971A5012661599 @default.
• W2130652971 hasAuthorship W2130652971A5013008945 @default.
• W2130652971 hasAuthorship W2130652971A5040601075 @default.
• W2130652971 hasAuthorship W2130652971A5042199822 @default.
• W2130652971 hasAuthorship W2130652971A5051166767 @default.
• W2130652971 hasAuthorship W2130652971A5083690478 @default.
• W2130652971 hasBestOaLocation W21306529711 @default.
• W2130652971 hasConcept C17991360 @default.
• W2130652971 hasConcept C203014093 @default.
• W2130652971 hasConcept C2778690821 @default.
• W2130652971 hasConcept C2780841837 @default.
• W2130652971 hasConcept C86803240 @default.
• W2130652971 hasConcept C8891405 @default.

• next