Matches in SemOpenAlex for { <https://semopenalex.org/work/W2130654327> ?p ?o ?g. }
- W2130654327 endingPage "7713" @default.
- W2130654327 startingPage "7706" @default.
- W2130654327 abstract "Abstract B cells are important for the development of most autoimmune diseases. B cell depletion immunotherapy has emerged as an effective treatment for several human autoimmune diseases, although it is unclear whether B cells are necessary for disease induction, autoantibody production, or disease progression. To address the role of B cells in a murine model of spontaneous autoimmune thyroiditis (SAT), B cells were depleted from adult NOD.H-2h4 mice using anti-mouse CD20 mAb. Anti-CD20 depleted most B cells in peripheral blood and cervical lymph nodes and 50–80% of splenic B cells. Flow cytometry analysis showed that marginal zone B cells in the spleen were relatively resistant to depletion by anti-CD20, whereas most follicular and transitional (T2) B cells were depleted after anti-CD20 treatment. When anti-CD20 was administered before development of SAT, development of SAT and anti-mouse thyroglobulin autoantibody responses were reduced. Anti-CD20 also reduced SAT severity and inhibited further increases in anti-mouse thyroglobulin autoantibodies when administered to mice that already had autoantibodies and thyroid inflammation. The results suggest that B cells are necessary for initiation as well as progression or maintenance of SAT in NOD.H-2h4 mice." @default.
- W2130654327 created "2016-06-24" @default.
- W2130654327 creator A5025139735 @default.
- W2130654327 creator A5026286781 @default.
- W2130654327 creator A5054028955 @default.
- W2130654327 creator A5069819200 @default.
- W2130654327 date "2008-06-01" @default.
- W2130654327 modified "2023-10-06" @default.
- W2130654327 title "B Cell Depletion Inhibits Spontaneous Autoimmune Thyroiditis in NOD.H-2h4 Mice" @default.
- W2130654327 cites W1508436155 @default.
- W2130654327 cites W1586126658 @default.
- W2130654327 cites W1597726496 @default.
- W2130654327 cites W1598354195 @default.
- W2130654327 cites W1633176708 @default.
- W2130654327 cites W1675831178 @default.
- W2130654327 cites W1750939701 @default.
- W2130654327 cites W1922855985 @default.
- W2130654327 cites W1935840505 @default.
- W2130654327 cites W1964453920 @default.
- W2130654327 cites W1966454866 @default.
- W2130654327 cites W1967908665 @default.
- W2130654327 cites W1968889356 @default.
- W2130654327 cites W1971723404 @default.
- W2130654327 cites W1979378256 @default.
- W2130654327 cites W1987870096 @default.
- W2130654327 cites W1997432556 @default.
- W2130654327 cites W1997452174 @default.
- W2130654327 cites W2006554573 @default.
- W2130654327 cites W2009606660 @default.
- W2130654327 cites W2021257197 @default.
- W2130654327 cites W2041205485 @default.
- W2130654327 cites W2046637170 @default.
- W2130654327 cites W2062553923 @default.
- W2130654327 cites W2063150581 @default.
- W2130654327 cites W2065260129 @default.
- W2130654327 cites W2070878729 @default.
- W2130654327 cites W2077297620 @default.
- W2130654327 cites W2083141507 @default.
- W2130654327 cites W2084653569 @default.
- W2130654327 cites W2085062445 @default.
- W2130654327 cites W2085072781 @default.
- W2130654327 cites W2089016290 @default.
- W2130654327 cites W2090669047 @default.
- W2130654327 cites W2094197485 @default.
- W2130654327 cites W2101580628 @default.
- W2130654327 cites W2105439871 @default.
- W2130654327 cites W2108556253 @default.
- W2130654327 cites W2110391738 @default.
- W2130654327 cites W2118994799 @default.
- W2130654327 cites W2119005151 @default.
- W2130654327 cites W2121133002 @default.
- W2130654327 cites W2122391163 @default.
- W2130654327 cites W2126232873 @default.
- W2130654327 cites W2126768274 @default.
- W2130654327 cites W2128857705 @default.
- W2130654327 cites W2131399528 @default.
- W2130654327 cites W2137421164 @default.
- W2130654327 cites W2137475696 @default.
- W2130654327 cites W2147022432 @default.
- W2130654327 cites W2149103649 @default.
- W2130654327 cites W2156180689 @default.
- W2130654327 cites W2157158772 @default.
- W2130654327 cites W2158166942 @default.
- W2130654327 cites W2167282621 @default.
- W2130654327 cites W2167318411 @default.
- W2130654327 cites W2168516002 @default.
- W2130654327 cites W4234049385 @default.
- W2130654327 cites W4236391507 @default.
- W2130654327 cites W4236954136 @default.
- W2130654327 cites W4250302047 @default.
- W2130654327 doi "https://doi.org/10.4049/jimmunol.180.11.7706" @default.
- W2130654327 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18490774" @default.
- W2130654327 hasPublicationYear "2008" @default.
- W2130654327 type Work @default.
- W2130654327 sameAs 2130654327 @default.
- W2130654327 citedByCount "45" @default.
- W2130654327 countsByYear W21306543272012 @default.
- W2130654327 countsByYear W21306543272013 @default.
- W2130654327 countsByYear W21306543272014 @default.
- W2130654327 countsByYear W21306543272015 @default.
- W2130654327 countsByYear W21306543272016 @default.
- W2130654327 countsByYear W21306543272017 @default.
- W2130654327 countsByYear W21306543272018 @default.
- W2130654327 countsByYear W21306543272019 @default.
- W2130654327 countsByYear W21306543272020 @default.
- W2130654327 countsByYear W21306543272022 @default.
- W2130654327 crossrefType "journal-article" @default.
- W2130654327 hasAuthorship W2130654327A5025139735 @default.
- W2130654327 hasAuthorship W2130654327A5026286781 @default.
- W2130654327 hasAuthorship W2130654327A5054028955 @default.
- W2130654327 hasAuthorship W2130654327A5069819200 @default.
- W2130654327 hasBestOaLocation W21306543271 @default.
- W2130654327 hasConcept C126322002 @default.
- W2130654327 hasConcept C134018914 @default.
- W2130654327 hasConcept C159654299 @default.
- W2130654327 hasConcept C163764329 @default.
- W2130654327 hasConcept C18031839 @default.
- W2130654327 hasConcept C203014093 @default.