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• W2130655115 abstract "Objective To compare the efficacy and tolerability of sublingual misoprostol with those of intramuscular 15-methyl-prostaglandin F2α (15-M-PG F2α) for cervical dilation prior to vacuum aspiration (VA) in first-trimester pregnancy termination. Methods Sixty pregnant women requesting pregnancy termination between the 9th and 12th week were randomized to receive 400 μg of sublingual misoprostol or an intramuscular injection of 125 μg of 15-M-PG F2α 2 h prior to vacuum aspiration. Baseline cervical dilation prior to vacuum aspiration was measured using Hegar's dilators. Other variables assessed included procedure duration, intraoperative blood loss, and associated adverse effects. Patient acceptability was assessed by questionnaires completed at the time of discharge from the hospital. Results Mean cervical dilation at vacuum aspiration was significantly greater in the misoprostol group than in the 15-M-PG F2α group (8.8 vs. 7.6 mm; P<0.01), and preoperative adverse effects were significantly less frequent in the sublingual misoprostol group (P<0.05). However, procedure duration and intraoperative blood loss were similar in both groups. The acceptability rates were 93.3% in the sublingual misoprostol group and 76.6% in the 15-M-PG F2α group, respectively; however, 6.6% patients in the sublingual misoprostol group thought that the tablets had an unpleasant taste. Conclusion Sublingual misoprostol appears to be an effective alternative to intramuscular 15-M-PG F2α for cervical dilation prior to vacuum aspiration in first trimester pregnancy. In addition, misoprostol is inexpensive and convenient to use and has higher patient acceptability rates." @default.
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• W2130655115 date "2004-12-08" @default.
• W2130655115 modified "2023-10-18" @default.
• W2130655115 title "Cervical priming with sublingual misoprostol vs. 15-methyl-prostaglandin F2α prior to surgical abortion" @default.
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• W2130655115 doi "https://doi.org/10.1016/j.ijgo.2004.10.010" @default.
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