FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2130684086> ?p ?o ?g. }

• W2130684086 abstract "Tolerance of the maternal immune system in pregnancy is important for successful pregnancy because the semiallogeneic fetus may be subject to antifetal responses. We examined maternal tolerance to the fetus using a murine system in which a model paternally inherited antigen, ovalbumin (OVA), is expressed exclusively in the fetus and placenta. By employing T cell receptor (TCR) transgenic mice specific for major histocompatibility complex class I- or class II-restricted epitopes of OVA (OT-I and OT-II) as mothers, we investigated the fate of fetus-specific CD8+ and CD4+ T cells, respectively, during gestation. Both OVA-specific CD8+ and CD4+ T cells displayed an activated phenotype in the peripheral lymphoid tissues of OVA-bred OT-I and OT-II mice, consistent with their encounter of fetal antigen. Whereas a small percentage of OVA-specific CD4+ T cells were deleted in the periphery and thymus of OVA-bred OT-II mice, with evidence of TCR downregulation in the remaining T cells, deletion and TCR downregulation were not observed in OVA-bred OT-I mice. Both CD4+ and CD8+ T cells upregulated inducible costimulator expression in response to the fetal antigen, but only CD4+ T cells consistently upregulated the inhibitory receptors programmed cell death 1 and cytotoxic T lymphocyte antigen-4. More regulatory T cells (Tregs) were present in pregnant OVA-bred than in WT-bred OT-II mice, revealing that Tregs expanded specifically in response to the fetal antigen. These data indicate that several mechanisms tolerize fetal antigen-specific maternal CD4+ T cells, whereas tolerance of fetal antigen-specific CD8+ T cells is less effective. The importance of these mechanisms is underscored by the finding that fetal loss occurs in OVA-bred OT-I but not OT-II mice." @default.
• W2130684086 created "2016-06-24" @default.
• W2130684086 creator A5022531995 @default.
• W2130684086 creator A5039176597 @default.
• W2130684086 creator A5062031828 @default.
• W2130684086 date "2013-10-01" @default.
• W2130684086 modified "2023-09-26" @default.
• W2130684086 title "Maternal CD4+ and CD8+ T Cell Tolerance Towards a Fetal Minor Histocompatibility Antigen in T Cell Receptor Transgenic Mice1" @default.
• W2130684086 cites W1509926487 @default.
• W2130684086 cites W1513619062 @default.
• W2130684086 cites W1536358893 @default.
• W2130684086 cites W1550488314 @default.
• W2130684086 cites W1626837556 @default.
• W2130684086 cites W1636840105 @default.
• W2130684086 cites W1964428726 @default.
• W2130684086 cites W1971416282 @default.
• W2130684086 cites W1971528193 @default.
• W2130684086 cites W1976853389 @default.
• W2130684086 cites W1984176234 @default.
• W2130684086 cites W1985270876 @default.
• W2130684086 cites W1989496524 @default.
• W2130684086 cites W1993714926 @default.
• W2130684086 cites W1993986867 @default.
• W2130684086 cites W1994864933 @default.
• W2130684086 cites W1996063613 @default.
• W2130684086 cites W1996166328 @default.
• W2130684086 cites W2015260577 @default.
• W2130684086 cites W2018020394 @default.
• W2130684086 cites W2020151812 @default.
• W2130684086 cites W2024299100 @default.
• W2130684086 cites W2029446327 @default.
• W2130684086 cites W2030121669 @default.
• W2130684086 cites W2033955925 @default.
• W2130684086 cites W2036698472 @default.
• W2130684086 cites W2042667235 @default.
• W2130684086 cites W2042792486 @default.
• W2130684086 cites W2055836763 @default.
• W2130684086 cites W2060392909 @default.
• W2130684086 cites W2062897922 @default.
• W2130684086 cites W2078710631 @default.
• W2130684086 cites W2084709577 @default.
• W2130684086 cites W2090166725 @default.
• W2130684086 cites W2092376347 @default.
• W2130684086 cites W2095909640 @default.
• W2130684086 cites W2096626405 @default.
• W2130684086 cites W2098494951 @default.
• W2130684086 cites W2101648782 @default.
• W2130684086 cites W2102608412 @default.
• W2130684086 cites W2106802298 @default.
• W2130684086 cites W2107849783 @default.
• W2130684086 cites W2113732030 @default.
• W2130684086 cites W2118634549 @default.
• W2130684086 cites W2121833389 @default.
• W2130684086 cites W2130694958 @default.
• W2130684086 cites W2132360503 @default.
• W2130684086 cites W2137938346 @default.
• W2130684086 cites W2139802799 @default.
• W2130684086 cites W2145074785 @default.
• W2130684086 cites W2145592052 @default.
• W2130684086 cites W2153077969 @default.
• W2130684086 cites W2153095488 @default.
• W2130684086 cites W2154903681 @default.
• W2130684086 cites W2155438304 @default.
• W2130684086 cites W2157202664 @default.
• W2130684086 cites W2161187897 @default.
• W2130684086 cites W2161371315 @default.
• W2130684086 cites W2162380170 @default.
• W2130684086 cites W2163703413 @default.
• W2130684086 cites W2164224099 @default.
• W2130684086 cites W2170548924 @default.
• W2130684086 cites W2172095803 @default.
• W2130684086 cites W4313308293 @default.
• W2130684086 cites W4313324525 @default.
• W2130684086 cites W4313333813 @default.
• W2130684086 doi "https://doi.org/10.1095/biolreprod.113.110445" @default.
• W2130684086 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4076394" @default.
• W2130684086 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24025737" @default.
• W2130684086 hasPublicationYear "2013" @default.
• W2130684086 type Work @default.
• W2130684086 sameAs 2130684086 @default.
• W2130684086 citedByCount "16" @default.
• W2130684086 countsByYear W21306840862014 @default.
• W2130684086 countsByYear W21306840862015 @default.
• W2130684086 countsByYear W21306840862016 @default.
• W2130684086 countsByYear W21306840862018 @default.
• W2130684086 countsByYear W21306840862019 @default.
• W2130684086 countsByYear W21306840862020 @default.
• W2130684086 countsByYear W21306840862021 @default.
• W2130684086 countsByYear W21306840862023 @default.
• W2130684086 crossrefType "journal-article" @default.
• W2130684086 hasAuthorship W2130684086A5022531995 @default.
• W2130684086 hasAuthorship W2130684086A5039176597 @default.
• W2130684086 hasAuthorship W2130684086A5062031828 @default.
• W2130684086 hasBestOaLocation W21306840861 @default.
• W2130684086 hasConcept C147483822 @default.
• W2130684086 hasConcept C154317977 @default.
• W2130684086 hasConcept C167672396 @default.
• W2130684086 hasConcept C172680121 @default.
• W2130684086 hasConcept C19317047 @default.
• W2130684086 hasConcept C202751555 @default.

• next