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- W2130688701 abstract "The gram-positive, endospore-forming bacterium Bacillus subtilis contains several membrane-bound c-type cytochromes. We have isolated a mutant pleiotropically deficient in cytochromes c. The responsible mutation resides in a gene which we have named ccdA (cytochrome c defective). This gene is located at 173 degrees on the B. subtilis chromosome. The ccdA gene was found to be specifically required for synthesis of cytochromes of the c type. CcdA is a predicted 26-kDa integral membrane protein with no clear similarity to any known cytochrome c biogenesis protein but seems to be related to a part of Escherichia coli DipZ/DsbD. The ccdA gene is cotranscribed with two other genes. These genes encode a putative 13.5-kDa single-domain response regulator, similar to B. subtilis CheY and Spo0F, and a predicted 18-kDa hydrophobic protein with no similarity to any protein in databases, respectively. Inactivation of the three genes showed that only ccdA is required for cytochrome c synthesis. The results also demonstrated that cytochromes of the c type are not needed for growth of B. subtilis." @default.
- W2130688701 created "2016-06-24" @default.
- W2130688701 creator A5009593011 @default.
- W2130688701 creator A5046702135 @default.
- W2130688701 creator A5061780742 @default.
- W2130688701 date "1997-03-01" @default.
- W2130688701 modified "2023-09-25" @default.
- W2130688701 title "Identification and characterization of the ccdA gene, required for cytochrome c synthesis in Bacillus subtilis" @default.
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- W2130688701 doi "https://doi.org/10.1128/jb.179.6.1962-1973.1997" @default.
- W2130688701 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/178920" @default.
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