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• W2130698045 abstract "Abstract Low levels of Cdk9 T-loop autophosphorylation in quiescent CD4+ T lymphocytes may limit RNA polymerase II elongation. The cellular kinase complex P-TEFb is composed of Cdk9 and cyclin T, and it is required for expression of most protein-coding genes by RNAP II. Cdk9 has been shown recently to be activated in cis by autophosphorylation of Thr186 in its T-loop. Using a phosphospecific Cdk9 antibody, we examined the level of Cdk9 T-loop phosphorylation in resting and activated CD4+ T lymphocytes. Cdk9 T-loop phosphorylation was found to be low-to-undetectable in resting CD4+ T lymphocytes, and upon activation by distinct stimuli, there is a rapid (&lt;1 h) increase in pCdk9 that does not require protein synthesis. The low level of Cdk9 T-loop phosphorylation was not to be a result of the absence of an associated regulatory cyclin partner. These observations suggest that autophosphorylation of the Cdk9 T-loop is repressed in resting CD4+ T lymphocytes. The low level of T-loop phosphorylation in resting cells is also reflected in a low level of phosphorylation of Ser2 in the carboxyl terminal domain of RNAP II, suggesting that lack of Cdk9 T-loop autophosphorylation may limit RNAP II elongation in quiescent CD4+ T lymphocytes." @default.
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• W2130698045 date "2009-09-09" @default.
• W2130698045 modified "2023-10-01" @default.
• W2130698045 title "Characterization of Cdk9 T-loop phosphorylation in resting and activated CD4+ T lymphocytes" @default.
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• W2130698045 doi "https://doi.org/10.1189/jlb.0509309" @default.
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