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• W2130711604 abstract "While anemia can result from many conditions including infectious diseases such as hook worm and malaria, micronutrient deficiencies of folate, vitamin A and vitamin B 12 , to name a few, and inherited blood disorders such as thalassemia, the consensus is that half of all anemia cases, world-wide, can be attributed to iron deficiency [3]. This assumption is based on evidence from surveys providing iron status information in addition to hemoglobin concentration and an understanding that conventional, staple-based diets, namely in resource poor settings, are low in bioavailable iron. Policy makers responded by encouraging iron supplementation to populations among whom anemia rates are known or expected to be elevated [4]. These programs have been very successful at reducing the burden of anemia and continue to provide a relatively inexpensive, valuable treatment and prevention strategy to vulnerable groups. In the same resource-limited environments were diets are poor, populations often experience increased exposure to infectious diseases that exacerbate the risk of blood loss and reduced hemoglobin. To complicate the public health response to anemia further, increasing evidence, most notably among children, suggests that there may be negative health consequences associated with providing untargeted iron supplementation to those who are regularly exposed to certain infectious diseases such as malaria [5] or enteric pathogens [6,7]. The disparate response to iron supplementation is thought to occur as a result of two mechanisms: 1) decreased epithelial integrity among those who are iron sufficient as a result of unabsorbed iron remaining in the gut and 2) increased enteric pathogen growth rates and virulence as a result of having a large supply of iron. Results from a recent study investigating the impact of consuming iron from drinking groundwater add complexity to the challenge of defining how to address anemia prevention through iron supplementation efficiently while adapting to unique environmental characteristics. One of the first studies exploring the association between consumption of naturally iron rich water and health outcomes showed that children in Bangladesh living in households with a tubewell iron concentration >1 mg/L of iron were significantly taller than those with groundwater iron <1 mg/L [8]. Subsequently, Spatone Iron-Plus, a marketed naturally occurring mineral water with an iron concentration of roughly 200 mg/L of ferrous sulphate, was found to provide a highly bioavailable iron source for pregnant women [9]. With an interest to explore water as a source of iron, many studies have been conducted in Brazil showing that water fortified with iron (and ascorbic acid) improves hemoglobin, iron status and growth [10]." @default.
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• W2130711604 date "2012-01-01" @default.
• W2130711604 modified "2023-09-30" @default.
• W2130711604 title "Iron in Groundwater: A Source for Anemia Prevention" @default.
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• W2130711604 doi "https://doi.org/10.4172/2376-1318.1000e111" @default.
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