Matches in SemOpenAlex for { <https://semopenalex.org/work/W2130731715> ?p ?o ?g. }
- W2130731715 endingPage "95" @default.
- W2130731715 startingPage "86" @default.
- W2130731715 abstract "Advances in breast cancer treatment have come from the recognition that pathways relevant to cancer cell biology could be identified and targeted. There is abundant in vitro, animal model, and epidemiologic evidence to suggest that the insulin-like growth factors (IGFs) play a role in regulating the malignant phenotype in breast cancer. Insulin-like growth factor action has been implicated in malignant transformation, cellular proliferation, protection from apoptosis, and metastasis. Because IGFs interact with specific cell surface receptors to affect intracellular signaling pathways, blockade of receptor activation could be a successful method to interrupt IGF-driven processes. In contrast to other transmembrane growth factor receptors, the IGF receptor requires activation by ligand. Thus, neutralization of ligand by a “target decoy” could be a useful method to inhibit IGF action. Use of an IGF-binding protein to inhibit activation of IGF receptors will be discussed. Semin Oncol 29 (suppl 11):86-95. Copyright 2002, Elsevier Science (USA). All rights reserved." @default.
- W2130731715 created "2016-06-24" @default.
- W2130731715 creator A5033966004 @default.
- W2130731715 date "2002-01-01" @default.
- W2130731715 modified "2023-10-11" @default.
- W2130731715 title "The insulin-like growth factor system as a treatment target in breast cancer" @default.
- W2130731715 cites W1534439131 @default.
- W2130731715 cites W1537879014 @default.
- W2130731715 cites W1555502876 @default.
- W2130731715 cites W1591360311 @default.
- W2130731715 cites W1606372667 @default.
- W2130731715 cites W1634064292 @default.
- W2130731715 cites W1768276284 @default.
- W2130731715 cites W1824970382 @default.
- W2130731715 cites W1848388033 @default.
- W2130731715 cites W1853387493 @default.
- W2130731715 cites W1871669466 @default.
- W2130731715 cites W1918073772 @default.
- W2130731715 cites W1931843124 @default.
- W2130731715 cites W1932574503 @default.
- W2130731715 cites W1945007559 @default.
- W2130731715 cites W1965283789 @default.
- W2130731715 cites W1969306557 @default.
- W2130731715 cites W1969974964 @default.
- W2130731715 cites W1970285990 @default.
- W2130731715 cites W1998961381 @default.
- W2130731715 cites W2000111014 @default.
- W2130731715 cites W2000923441 @default.
- W2130731715 cites W2002120032 @default.
- W2130731715 cites W2004205588 @default.
- W2130731715 cites W2008447360 @default.
- W2130731715 cites W2008787181 @default.
- W2130731715 cites W2009928329 @default.
- W2130731715 cites W2012940389 @default.
- W2130731715 cites W2013523350 @default.
- W2130731715 cites W2018342641 @default.
- W2130731715 cites W2020809609 @default.
- W2130731715 cites W2031997272 @default.
- W2130731715 cites W2032850422 @default.
- W2130731715 cites W2045516074 @default.
- W2130731715 cites W2047979401 @default.
- W2130731715 cites W2048430369 @default.
- W2130731715 cites W2051340804 @default.
- W2130731715 cites W2053401836 @default.
- W2130731715 cites W2060999361 @default.
- W2130731715 cites W2061713372 @default.
- W2130731715 cites W2062860025 @default.
- W2130731715 cites W2071892147 @default.
- W2130731715 cites W2072321616 @default.
- W2130731715 cites W2081075932 @default.
- W2130731715 cites W2081742266 @default.
- W2130731715 cites W2082501870 @default.
- W2130731715 cites W2083637184 @default.
- W2130731715 cites W2084081202 @default.
- W2130731715 cites W2087258136 @default.
- W2130731715 cites W2087729478 @default.
- W2130731715 cites W2090099477 @default.
- W2130731715 cites W2092754486 @default.
- W2130731715 cites W2093635855 @default.
- W2130731715 cites W2095064031 @default.
- W2130731715 cites W2095546315 @default.
- W2130731715 cites W2098524771 @default.
- W2130731715 cites W2098767548 @default.
- W2130731715 cites W2100937050 @default.
- W2130731715 cites W2102033127 @default.
- W2130731715 cites W2102437478 @default.
- W2130731715 cites W2102979193 @default.
- W2130731715 cites W2112340015 @default.
- W2130731715 cites W2116743865 @default.
- W2130731715 cites W2117350664 @default.
- W2130731715 cites W2117774433 @default.
- W2130731715 cites W2124549288 @default.
- W2130731715 cites W2127006469 @default.
- W2130731715 cites W2128551678 @default.
- W2130731715 cites W2130788909 @default.
- W2130731715 cites W2132846837 @default.
- W2130731715 cites W2134674714 @default.
- W2130731715 cites W2137108912 @default.
- W2130731715 cites W2138762676 @default.
- W2130731715 cites W2140491527 @default.
- W2130731715 cites W2140764109 @default.
- W2130731715 cites W2140984295 @default.
- W2130731715 cites W2144678487 @default.
- W2130731715 cites W2145518958 @default.
- W2130731715 cites W2148301853 @default.
- W2130731715 cites W2154802841 @default.
- W2130731715 cites W2156047304 @default.
- W2130731715 cites W2160466713 @default.
- W2130731715 cites W2168698481 @default.
- W2130731715 cites W2170071643 @default.
- W2130731715 cites W2170992136 @default.
- W2130731715 cites W2222638000 @default.
- W2130731715 cites W2319017688 @default.
- W2130731715 cites W2321112275 @default.
- W2130731715 cites W2328665307 @default.
- W2130731715 cites W2329798361 @default.
- W2130731715 cites W2418186096 @default.
- W2130731715 cites W2427721238 @default.