FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2130734489> ?p ?o ?g. }

• W2130734489 endingPage "147" @default.
• W2130734489 startingPage "138" @default.
• W2130734489 abstract "Tat, the transactivation factor of human immunodeficiency virus type 1 (HIV-1), represents one of the major players mediating the loss of CD4-positive T-lymphocytes in HIV-1-infected patients, primarily due to the ability of Tat to trigger apoptosis. However, the molecular events underlying this process remain elusive. In this study, we provide evidence that Tat interacts with Eg5, a microtubule-associated motor protein, and allosterically modulates the ATPase activity of Eg5 by affecting ADP release from the enzyme's active centre. This action of Tat impairs the formation of the mitotic spindle and activates the spindle checkpoint, thereby blocking cell cycle progression at mitosis and leading to apoptosis. Further studies reveal that lysine 85 in the carboxyl terminus of Tat is critical for its interaction with Eg5 and hence its effects on Eg5 activity, mitotic progression, and apoptosis. These findings identify Tat as a viral regulator of Eg5 and provide novel insights into the mechanisms of action of Tat in mediating the reduction of CD4-positive T-lymphocytes." @default.
• W2130734489 created "2016-06-24" @default.
• W2130734489 creator A5007035858 @default.
• W2130734489 creator A5010479652 @default.
• W2130734489 creator A5017353282 @default.
• W2130734489 creator A5022169204 @default.
• W2130734489 creator A5022957259 @default.
• W2130734489 creator A5058127847 @default.
• W2130734489 creator A5065615188 @default.
• W2130734489 creator A5090043165 @default.
• W2130734489 date "2014-03-28" @default.
• W2130734489 modified "2023-09-25" @default.
• W2130734489 title "Modulation of Eg5 activity contributes to mitotic spindle checkpoint activation and Tat-mediated apoptosis in CD4-positive T-lymphocytes" @default.
• W2130734489 cites W1497532563 @default.
• W2130734489 cites W1564126799 @default.
• W2130734489 cites W1727897997 @default.
• W2130734489 cites W1966680971 @default.
• W2130734489 cites W1979013550 @default.
• W2130734489 cites W1987045145 @default.
• W2130734489 cites W2001634471 @default.
• W2130734489 cites W2004732690 @default.
• W2130734489 cites W2005010803 @default.
• W2130734489 cites W2007496937 @default.
• W2130734489 cites W2021188590 @default.
• W2130734489 cites W2026091658 @default.
• W2130734489 cites W2027459341 @default.
• W2130734489 cites W2029305083 @default.
• W2130734489 cites W2035472375 @default.
• W2130734489 cites W2040090588 @default.
• W2130734489 cites W2042143995 @default.
• W2130734489 cites W2046598379 @default.
• W2130734489 cites W2052212101 @default.
• W2130734489 cites W2052762012 @default.
• W2130734489 cites W2052785715 @default.
• W2130734489 cites W2054784687 @default.
• W2130734489 cites W2056605370 @default.
• W2130734489 cites W205758415 @default.
• W2130734489 cites W2057633014 @default.
• W2130734489 cites W2063769322 @default.
• W2130734489 cites W2074811497 @default.
• W2130734489 cites W2075587912 @default.
• W2130734489 cites W2079156590 @default.
• W2130734489 cites W2081200884 @default.
• W2130734489 cites W2104392640 @default.
• W2130734489 cites W2120704505 @default.
• W2130734489 cites W2143810926 @default.
• W2130734489 cites W2144390370 @default.
• W2130734489 cites W2146191841 @default.
• W2130734489 cites W2146314877 @default.
• W2130734489 cites W2161959257 @default.
• W2130734489 cites W2166235318 @default.
• W2130734489 cites W4240479615 @default.
• W2130734489 doi "https://doi.org/10.1002/path.4333" @default.
• W2130734489 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24488929" @default.
• W2130734489 hasPublicationYear "2014" @default.
• W2130734489 type Work @default.
• W2130734489 sameAs 2130734489 @default.
• W2130734489 citedByCount "19" @default.
• W2130734489 countsByYear W21307344892014 @default.
• W2130734489 countsByYear W21307344892015 @default.
• W2130734489 countsByYear W21307344892016 @default.
• W2130734489 countsByYear W21307344892017 @default.
• W2130734489 countsByYear W21307344892018 @default.
• W2130734489 countsByYear W21307344892020 @default.
• W2130734489 countsByYear W21307344892021 @default.
• W2130734489 countsByYear W21307344892022 @default.
• W2130734489 crossrefType "journal-article" @default.
• W2130734489 hasAuthorship W2130734489A5007035858 @default.
• W2130734489 hasAuthorship W2130734489A5010479652 @default.
• W2130734489 hasAuthorship W2130734489A5017353282 @default.
• W2130734489 hasAuthorship W2130734489A5022169204 @default.
• W2130734489 hasAuthorship W2130734489A5022957259 @default.
• W2130734489 hasAuthorship W2130734489A5058127847 @default.
• W2130734489 hasAuthorship W2130734489A5065615188 @default.
• W2130734489 hasAuthorship W2130734489A5090043165 @default.
• W2130734489 hasConcept C104317684 @default.
• W2130734489 hasConcept C1292079 @default.
• W2130734489 hasConcept C1491633281 @default.
• W2130734489 hasConcept C190283241 @default.
• W2130734489 hasConcept C20418707 @default.
• W2130734489 hasConcept C47432576 @default.
• W2130734489 hasConcept C55493867 @default.
• W2130734489 hasConcept C85813293 @default.
• W2130734489 hasConcept C86339819 @default.
• W2130734489 hasConcept C86803240 @default.
• W2130734489 hasConcept C93304396 @default.
• W2130734489 hasConcept C95444343 @default.
• W2130734489 hasConceptScore W2130734489C104317684 @default.
• W2130734489 hasConceptScore W2130734489C1292079 @default.
• W2130734489 hasConceptScore W2130734489C1491633281 @default.
• W2130734489 hasConceptScore W2130734489C190283241 @default.
• W2130734489 hasConceptScore W2130734489C20418707 @default.
• W2130734489 hasConceptScore W2130734489C47432576 @default.
• W2130734489 hasConceptScore W2130734489C55493867 @default.
• W2130734489 hasConceptScore W2130734489C85813293 @default.
• W2130734489 hasConceptScore W2130734489C86339819 @default.
• W2130734489 hasConceptScore W2130734489C86803240 @default.
• W2130734489 hasConceptScore W2130734489C93304396 @default.

• next