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- W2130751639 abstract "Diacylglycerol has been hypothesized to mediate the positive inotropic response of myocardium to the α-adrenergic agonists angiotensin II and endothelin. The mechanism of action of diacylglycerol was examined here in adult rat ventricular myocytes by releasing dioctanoylglycerol (diC 8 ) intracellularly from a caged compound while monitoring Ca 2+ transients and pH with fluorescent indicators. DiC 8 caused a three- to fourfold increase in twitch amplitude and a twofold increase in the systolic Ca 2+ transient. No other parameter was consistently influenced by diC 8 , including the kinetics of Ca 2+ cycling, the Ca 2+ content of the sarcoplasmic reticulum, or the myofilament Ca 2+ sensitivity. DiC 8 also had no detectable effect on intracellular pH or Na + /H + antiport activity. Consistent with this finding, the Na + /H + exchange inhibitor N-ethylisopropyl amiloride was without effect on the positive inotropic response to diC 8 . The marked enhancement of systolic Ca 2+ by diC 8 suggests that the process of excitation-contraction coupling is an important and possibly preferred target of diacylglycerol-protein kinase C signaling in myocardium." @default.
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- W2130751639 date "1998-10-01" @default.
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- W2130751639 title "Role of intracellular Ca<sup>2+</sup>and pH in positive inotropic response of cardiomyocytes to diacylglycerol" @default.
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- W2130751639 doi "https://doi.org/10.1152/ajpheart.1998.275.4.h1473" @default.
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