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• W2130754064 abstract "Abstract Purpose: Flaxseed, the richest source of mammalian lignan precursors, has previously been shown to reduce the growth of tumors in rats. This study examined, in a randomized double-blind placebo-controlled clinical trial, the effects of dietary flaxseed on tumor biological markers and urinary lignan excretion in postmenopausal patients with newly diagnosed breast cancer. Experimental Design: Patients were randomized to daily intake of either a 25 g flaxseed-containing muffin (n = 19) or a control (placebo) muffin (n = 13). At the time of diagnosis and again at definitive surgery, tumor tissue was analyzed for the rate of tumor cell proliferation (Ki-67 labeling index, primary end point), apoptosis, c-erbB2 expression, and estrogen and progesterone receptor levels. Twenty-four–hour urine samples were analyzed for lignans, and 3-day diet records were evaluated for macronutrient and caloric intake. Mean treatment times were 39 and 32 days in the placebo and flaxseed groups, respectively. Results: Reductions in Ki-67 labeling index (34.2%; P = 0.001) and in c-erbB2 expression (71.0%; P = 0.003) and an increase in apoptosis (30.7%; P = 0.007) were observed in the flaxseed, but not in the placebo group. No significant differences in caloric and macronutrient intake were seen between groups and between pre- and posttreatment periods. A significant increase in mean urinary lignan excretion was observed in the flaxseed group (1,300%; P &lt; 0.01) compared with placebo controls. The total intake of flaxseed was correlated with changes in c-erbB2 score (r = −0.373; P = 0.036) and apoptotic index (r = 0.495; P &lt; 0.004). Conclusion: Dietary flaxseed has the potential to reduce tumor growth in patients with breast cancer." @default.
• W2130754064 created "2016-06-24" @default.
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• W2130754064 date "2005-05-15" @default.
• W2130754064 modified "2023-09-27" @default.
• W2130754064 title "Dietary Flaxseed Alters Tumor Biological Markers in Postmenopausal Breast Cancer" @default.
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• W2130754064 doi "https://doi.org/10.1158/1078-0432.ccr-04-2326" @default.
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