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• W2130754579 endingPage "e1000727" @default.
• W2130754579 startingPage "e1000727" @default.
• W2130754579 abstract "The accuracy of protein structures, particularly their binding sites, is essential for the success of modeling protein complexes. Computationally inexpensive methodology is required for genome-wide modeling of such structures. For systematic evaluation of potential accuracy in high-throughput modeling of binding sites, a statistical analysis of target-template sequence alignments was performed for a representative set of protein complexes. For most of the complexes, alignments containing all residues of the interface were found. The full interface alignments were obtained even in the case of poor alignments where a relatively small part of the target sequence (as low as 40%) aligned to the template sequence, with a low overall alignment identity (<30%). Although such poor overall alignments might be considered inadequate for modeling of whole proteins, the alignment of the interfaces was strong enough for docking. In the set of homology models built on these alignments, one third of those ranked 1 by a simple sequence identity criteria had RMSD<5 A, the accuracy suitable for low-resolution template free docking. Such models corresponded to multi-domain target proteins, whereas for single-domain proteins the best models had 5 A<RMSD<10 A, the accuracy suitable for less sensitive structure-alignment methods. Overall, approximately 50% of complexes with the interfaces modeled by high-throughput techniques had accuracy suitable for meaningful docking experiments. This percentage will grow with the increasing availability of co-crystallized protein-protein complexes." @default.
• W2130754579 created "2016-06-24" @default.
• W2130754579 creator A5013394507 @default.
• W2130754579 creator A5050411996 @default.
• W2130754579 date "2010-04-01" @default.
• W2130754579 modified "2023-09-27" @default.
• W2130754579 title "Accuracy of Protein-Protein Binding Sites in High-Throughput Template-Based Modeling" @default.
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• W2130754579 doi "https://doi.org/10.1371/journal.pcbi.1000727" @default.
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