FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2130756483> ?p ?o ?g. }

• W2130756483 endingPage "3881" @default.
• W2130756483 startingPage "3876" @default.
• W2130756483 abstract "ETS1 is a cellular homologue of the product of the viral ets oncogene of the E26 virus, and it functions as a tissue-specific transcription factor. It plays an important role in cell proliferation, differentiation, lymphoid cell development, transformation, angiogenesis, and apoptosis. ETS1 controls the expression of critical genes involved in these processes by binding to ets binding sites present in the transcriptional regulatory regions. The ETS1 gene generates two proteins, p51 and a spliced variant, p42, lacking exon VII. In this paper we show that p42-ETS1 expression bypasses the damaged Fas-induced apoptotic pathway in DLD1 colon carcinoma cells by up-regulating interleukin 1beta-converting enzyme (ICE)/caspase-1 and causes these cancer cells to become susceptible to the effects of the normal apoptosis activation system. ICE/caspase-1 is a redundant system in many cells and tissues, and here we demonstrate that it is important in activating apoptosis in cells where the normal apoptosis pathway is blocked. Blocking ICE/caspase-1 activity by using specific inhibitors of this protease prevents the p42-ETS1-induced apoptosis from occurring, indicating that the induced ICE/caspase-1 enzyme is responsible for killing the cancer cells. p42-ETS1 activates a critical alternative apoptosis pathway in cancer cells that are resistant to normal immune attack, and thus it may be useful as an anticancer therapeutic." @default.
• W2130756483 created "2016-06-24" @default.
• W2130756483 creator A5002275826 @default.
• W2130756483 creator A5045144563 @default.
• W2130756483 creator A5056516079 @default.
• W2130756483 date "1999-03-30" @default.
• W2130756483 modified "2023-10-05" @default.
• W2130756483 title "The p42 variant of ETS1 protein rescues defective Fas-induced apoptosis in colon carcinoma cells" @default.
• W2130756483 cites W1533906146 @default.
• W2130756483 cites W1550136826 @default.
• W2130756483 cites W1557686543 @default.
• W2130756483 cites W1660472675 @default.
• W2130756483 cites W1967294608 @default.
• W2130756483 cites W1967662297 @default.
• W2130756483 cites W1972805802 @default.
• W2130756483 cites W1973792489 @default.
• W2130756483 cites W1981114387 @default.
• W2130756483 cites W1987785848 @default.
• W2130756483 cites W1989963027 @default.
• W2130756483 cites W1990917512 @default.
• W2130756483 cites W2007689766 @default.
• W2130756483 cites W2008261126 @default.
• W2130756483 cites W2017728303 @default.
• W2130756483 cites W2019107186 @default.
• W2130756483 cites W2030892254 @default.
• W2130756483 cites W2032417513 @default.
• W2130756483 cites W2036771141 @default.
• W2130756483 cites W2039355845 @default.
• W2130756483 cites W2041466047 @default.
• W2130756483 cites W2042552053 @default.
• W2130756483 cites W2045870686 @default.
• W2130756483 cites W2046570296 @default.
• W2130756483 cites W2047056744 @default.
• W2130756483 cites W2048620835 @default.
• W2130756483 cites W2049110705 @default.
• W2130756483 cites W2055049810 @default.
• W2130756483 cites W2061108580 @default.
• W2130756483 cites W2061359959 @default.
• W2130756483 cites W2070664130 @default.
• W2130756483 cites W2072502723 @default.
• W2130756483 cites W2078297328 @default.
• W2130756483 cites W2089660502 @default.
• W2130756483 cites W2089915271 @default.
• W2130756483 cites W2091548699 @default.
• W2130756483 cites W2093392246 @default.
• W2130756483 cites W2094334993 @default.
• W2130756483 cites W2105263387 @default.
• W2130756483 cites W2106410559 @default.
• W2130756483 cites W2110357545 @default.
• W2130756483 cites W2129793865 @default.
• W2130756483 cites W2139360111 @default.
• W2130756483 cites W2147751847 @default.
• W2130756483 cites W2163856919 @default.
• W2130756483 cites W2168747001 @default.
• W2130756483 cites W2326870974 @default.
• W2130756483 cites W2421374720 @default.
• W2130756483 cites W2422683323 @default.
• W2130756483 cites W2435029438 @default.
• W2130756483 cites W2564590762 @default.
• W2130756483 cites W4250256124 @default.
• W2130756483 cites W4362205050 @default.
• W2130756483 doi "https://doi.org/10.1073/pnas.96.7.3876" @default.
• W2130756483 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/22388" @default.
• W2130756483 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10097131" @default.
• W2130756483 hasPublicationYear "1999" @default.
• W2130756483 type Work @default.
• W2130756483 sameAs 2130756483 @default.
• W2130756483 citedByCount "46" @default.
• W2130756483 countsByYear W21307564832015 @default.
• W2130756483 countsByYear W21307564832016 @default.
• W2130756483 countsByYear W21307564832019 @default.
• W2130756483 countsByYear W21307564832021 @default.
• W2130756483 crossrefType "journal-article" @default.
• W2130756483 hasAuthorship W2130756483A5002275826 @default.
• W2130756483 hasAuthorship W2130756483A5045144563 @default.
• W2130756483 hasAuthorship W2130756483A5056516079 @default.
• W2130756483 hasBestOaLocation W21307564831 @default.
• W2130756483 hasConcept C104317684 @default.
• W2130756483 hasConcept C153911025 @default.
• W2130756483 hasConcept C190283241 @default.
• W2130756483 hasConcept C2780538058 @default.
• W2130756483 hasConcept C31573885 @default.
• W2130756483 hasConcept C48297814 @default.
• W2130756483 hasConcept C502942594 @default.
• W2130756483 hasConcept C54355233 @default.
• W2130756483 hasConcept C86339819 @default.
• W2130756483 hasConcept C86803240 @default.
• W2130756483 hasConcept C95444343 @default.
• W2130756483 hasConcept C98424977 @default.
• W2130756483 hasConceptScore W2130756483C104317684 @default.
• W2130756483 hasConceptScore W2130756483C153911025 @default.
• W2130756483 hasConceptScore W2130756483C190283241 @default.
• W2130756483 hasConceptScore W2130756483C2780538058 @default.
• W2130756483 hasConceptScore W2130756483C31573885 @default.
• W2130756483 hasConceptScore W2130756483C48297814 @default.
• W2130756483 hasConceptScore W2130756483C502942594 @default.
• W2130756483 hasConceptScore W2130756483C54355233 @default.
• W2130756483 hasConceptScore W2130756483C86339819 @default.

• next