FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2130756507> ?p ?o ?g. }

• W2130756507 endingPage "398" @default.
• W2130756507 startingPage "388" @default.
• W2130756507 abstract "The mechanism by which osteoblasts (OB) interact and modulate the phenotype and proliferation of T lymphocytes during inflammation is not well known. The effects of two regulatory cytokines, TNFalpha and IFNgamma, on the expression of CD54 (ICAM-1) and CD106 (VCAM-1) adhesion molecules and the CXCR3 ligands (CXCL9, CXCL10, CXCL11), were assessed in a primary culture of human OB by real-time PCR, flow cytometry, and immunohistochemistry. In addition, we functionally evaluated the recruitment and proliferation of T lymphocytes grown with resting or stimulated OB. According to the present data IFNgamma, either alone or in combination with TNFalpha, significantly up-regulates the expression of CD54 and CD106 and induces the expression and release of CXCL9, CXCL10, CXCL11 in OB. The supernatant of TNFalpha- and IFNgamma-activated OB induces the recruitment of T lymphocytes more significantly than stimulation by CXCR3 ligands. T lymphocyte proliferation is significantly enhanced by direct contact with TNFalpha- and IFNgamma-activated OB or by incubation with the supernatant of TNFalpha- and IFNgamma-activated OB. Blocking experiments with anti-CD11a, anti-CD49d, anti-CXCR3, and Bordetella pertussis toxin demonstrate that adhesion molecules and the CXCR3 chemokine receptor play a key role in the proliferation of T lymphocytes. The present study demonstrates the involvement of adhesion molecules (CD11a and CD49d) and chemokine receptor (CXCR3) in the mechanism by which OB recruit, interact, and modulate T lymphocyte proliferation under inflammatory conditions." @default.
• W2130756507 created "2016-06-24" @default.
• W2130756507 creator A5002892440 @default.
• W2130756507 creator A5014587405 @default.
• W2130756507 creator A5026773834 @default.
• W2130756507 creator A5033086164 @default.
• W2130756507 creator A5047697868 @default.
• W2130756507 creator A5050371900 @default.
• W2130756507 creator A5050939429 @default.
• W2130756507 date "2003-09-23" @default.
• W2130756507 modified "2023-10-09" @default.
• W2130756507 title "Recruitment and proliferation of T lymphocytes is supported by IFN?- and TNF?-activated human osteoblasts: Involvement of CD54 (ICAM-1) and CD106 (VCAM-1) adhesion molecules and CXCR3 chemokine receptor" @default.
• W2130756507 cites W1561778447 @default.
• W2130756507 cites W1570147293 @default.
• W2130756507 cites W1599302006 @default.
• W2130756507 cites W1607601839 @default.
• W2130756507 cites W1630755947 @default.
• W2130756507 cites W1639854378 @default.
• W2130756507 cites W1817160237 @default.
• W2130756507 cites W1817248083 @default.
• W2130756507 cites W1964476412 @default.
• W2130756507 cites W1965427749 @default.
• W2130756507 cites W1968284075 @default.
• W2130756507 cites W1974384763 @default.
• W2130756507 cites W1979430966 @default.
• W2130756507 cites W1980243238 @default.
• W2130756507 cites W1988210099 @default.
• W2130756507 cites W1994529997 @default.
• W2130756507 cites W2004870721 @default.
• W2130756507 cites W2042626190 @default.
• W2130756507 cites W2046412495 @default.
• W2130756507 cites W2057285010 @default.
• W2130756507 cites W2058898263 @default.
• W2130756507 cites W2060657825 @default.
• W2130756507 cites W2066259773 @default.
• W2130756507 cites W2079704279 @default.
• W2130756507 cites W2081596482 @default.
• W2130756507 cites W2089866195 @default.
• W2130756507 cites W2101523399 @default.
• W2130756507 cites W2102862146 @default.
• W2130756507 cites W2107798540 @default.
• W2130756507 cites W2113080819 @default.
• W2130756507 cites W2136638612 @default.
• W2130756507 cites W2137421304 @default.
• W2130756507 cites W2143920564 @default.
• W2130756507 cites W2158045591 @default.
• W2130756507 cites W2169346414 @default.
• W2130756507 cites W2383407574 @default.
• W2130756507 cites W2461358464 @default.
• W2130756507 cites W4313376938 @default.
• W2130756507 doi "https://doi.org/10.1002/jcp.10427" @default.
• W2130756507 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14755544" @default.
• W2130756507 hasPublicationYear "2003" @default.
• W2130756507 type Work @default.
• W2130756507 sameAs 2130756507 @default.
• W2130756507 citedByCount "26" @default.
• W2130756507 countsByYear W21307565072012 @default.
• W2130756507 countsByYear W21307565072013 @default.
• W2130756507 countsByYear W21307565072014 @default.
• W2130756507 countsByYear W21307565072015 @default.
• W2130756507 countsByYear W21307565072016 @default.
• W2130756507 countsByYear W21307565072017 @default.
• W2130756507 countsByYear W21307565072018 @default.
• W2130756507 countsByYear W21307565072019 @default.
• W2130756507 crossrefType "journal-article" @default.
• W2130756507 hasAuthorship W2130756507A5002892440 @default.
• W2130756507 hasAuthorship W2130756507A5014587405 @default.
• W2130756507 hasAuthorship W2130756507A5026773834 @default.
• W2130756507 hasAuthorship W2130756507A5033086164 @default.
• W2130756507 hasAuthorship W2130756507A5047697868 @default.
• W2130756507 hasAuthorship W2130756507A5050371900 @default.
• W2130756507 hasAuthorship W2130756507A5050939429 @default.
• W2130756507 hasConcept C12823836 @default.
• W2130756507 hasConcept C13373296 @default.
• W2130756507 hasConcept C13425408 @default.
• W2130756507 hasConcept C143172330 @default.
• W2130756507 hasConcept C153911025 @default.
• W2130756507 hasConcept C16224149 @default.
• W2130756507 hasConcept C170493617 @default.
• W2130756507 hasConcept C17991360 @default.
• W2130756507 hasConcept C185592680 @default.
• W2130756507 hasConcept C185946421 @default.
• W2130756507 hasConcept C203014093 @default.
• W2130756507 hasConcept C25532541 @default.
• W2130756507 hasConcept C2776985958 @default.
• W2130756507 hasConcept C55493867 @default.
• W2130756507 hasConcept C5858377 @default.
• W2130756507 hasConcept C86803240 @default.
• W2130756507 hasConcept C95444343 @default.
• W2130756507 hasConceptScore W2130756507C12823836 @default.
• W2130756507 hasConceptScore W2130756507C13373296 @default.
• W2130756507 hasConceptScore W2130756507C13425408 @default.
• W2130756507 hasConceptScore W2130756507C143172330 @default.
• W2130756507 hasConceptScore W2130756507C153911025 @default.
• W2130756507 hasConceptScore W2130756507C16224149 @default.
• W2130756507 hasConceptScore W2130756507C170493617 @default.
• W2130756507 hasConceptScore W2130756507C17991360 @default.
• W2130756507 hasConceptScore W2130756507C185592680 @default.

• next