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• W2130759072 abstract "Seven patients (mean age, 37.6 years; 5 women) had several weeks of gluten sensitivity (GS)-like symptoms; 2 had flu-like symptom prodromes. The 7 cases had morphologically similar biopsy specimens; all tissue fragments had uniform injury—increased lymphoplasmacytic lamina propria inflammation, moderate to complete villous flattening, numerous crypt mitoses, and markedly increased villous intraepithelial lymphocytes (IELs). All patients were diagnosed with GS and prescribed a gluten-free diet; all returned 9 to 38 weeks later questioning their diagnosis because symptoms had resolved substantially or completely. Clinical improvement was unrelated to gluten abstinence or ingestion. Repeated endoscopy and colonoscopy performed 4.1 to 16 months later showed normal mucosa in all 7 patients. Diseases other than GS can cause marked villous flattening and increased villous IELs in adults. The cause of small bowel mucosal injury is unknown. A similar non-GS–associated clinicopathologic complex, assumed to be due to a protracted viral enteritis or slow regression of a virus-induced immune reaction, occurs in children. The temporal aspects of symptom improvement and mucosal restitution in these 7 patients are similar to “acute self-limited colitis.” An overly exuberant immune response to an infectious agent is possible." @default.
• W2130759072 created "2016-06-24" @default.
• W2130759072 creator A5080604064 @default.
• W2130759072 date "2004-04-01" @default.
• W2130759072 modified "2023-09-26" @default.
• W2130759072 title "Non-Gluten Sensitivity-Related Small Bowel Villous Flattening With Increased Intraepithelial Lymphocytes Not All That Flattens Is Celiac Sprue" @default.
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• W2130759072 doi "https://doi.org/10.1309/10fc-nctc-56nm-n0ye" @default.
• W2130759072 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15487452" @default.
• W2130759072 hasPublicationYear "2004" @default.
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