Matches in SemOpenAlex for { <https://semopenalex.org/work/W2130767568> ?p ?o ?g. }
- W2130767568 endingPage "4177" @default.
- W2130767568 startingPage "4168" @default.
- W2130767568 abstract "In species with temperature-dependent sex determination, embryonic gonadal differentiation can be modified by exposure to exogenous chemicals such as environmental contaminants. Although phenotypic outcomes of such events are well documented, the underlying molecular mechanisms are rarely described. Here we examine the genetic and epigenetic effect of the embryonic exposure to polychlorinated biphenyls (PCBs) on gonad differentiation in red-eared slider turtles (Trachemys scripta). Some PCB congeners are without effect whereas others synergize to alter sex determination in this species. Application of two potent PCB congeners alter the physiological processes of gonad development normally dictated by the male-producing temperature (MPT), resulting sex ratios significantly biased toward female hatchlings. Of these PCB-induced females, oviduct formation is prominently distorted regardless of ovary development. Further, gonadal expression of ovarian markers, aromatase, FoxL2, and Rspo1, is activated whereas testicular markers, Dmrt1 and Sox9, are suppressed compared with typical expression patterns observed at MPT. DNA methylation profiles of the aromatase promoter in PCB-treated gonads do not follow the typical methylation pattern observed in embryos incubating at female-producing temperature. Rather, the MPT-typical methylation profiles is retained despite the induced ovarian formation. Overall, our studies demonstrate that PCB exposure alters the transcriptional profiles of genes responsible for gonadal differentiation but does not re-establish the epigenetic marks of the aromatase promoter normally set by incubation temperatures in embryonic gonads." @default.
- W2130767568 created "2016-06-24" @default.
- W2130767568 creator A5006173115 @default.
- W2130767568 creator A5008384624 @default.
- W2130767568 creator A5018129234 @default.
- W2130767568 date "2014-11-01" @default.
- W2130767568 modified "2023-10-18" @default.
- W2130767568 title "Embryonic PCB Exposure Alters Phenotypic, Genetic, and Epigenetic Profiles in Turtle Sex Determination, a Biomarker of Environmental Contamination" @default.
- W2130767568 cites W1969073300 @default.
- W2130767568 cites W1970793060 @default.
- W2130767568 cites W1980887286 @default.
- W2130767568 cites W1982690749 @default.
- W2130767568 cites W1985956131 @default.
- W2130767568 cites W1991812784 @default.
- W2130767568 cites W1995675407 @default.
- W2130767568 cites W1995827355 @default.
- W2130767568 cites W1998835536 @default.
- W2130767568 cites W1999262954 @default.
- W2130767568 cites W2002021255 @default.
- W2130767568 cites W2010801066 @default.
- W2130767568 cites W2018628382 @default.
- W2130767568 cites W2022183167 @default.
- W2130767568 cites W2026454378 @default.
- W2130767568 cites W2028203614 @default.
- W2130767568 cites W2030422353 @default.
- W2130767568 cites W2036100177 @default.
- W2130767568 cites W2044589217 @default.
- W2130767568 cites W2056023544 @default.
- W2130767568 cites W2062309674 @default.
- W2130767568 cites W2064778500 @default.
- W2130767568 cites W2077086080 @default.
- W2130767568 cites W2085992155 @default.
- W2130767568 cites W2086138574 @default.
- W2130767568 cites W2092195813 @default.
- W2130767568 cites W2098578504 @default.
- W2130767568 cites W2101037833 @default.
- W2130767568 cites W2104821090 @default.
- W2130767568 cites W2108445907 @default.
- W2130767568 cites W2110263370 @default.
- W2130767568 cites W2114257886 @default.
- W2130767568 cites W2115263123 @default.
- W2130767568 cites W2116112998 @default.
- W2130767568 cites W2117609465 @default.
- W2130767568 cites W2121153131 @default.
- W2130767568 cites W2140897200 @default.
- W2130767568 cites W2154968546 @default.
- W2130767568 cites W2157245931 @default.
- W2130767568 cites W2161749375 @default.
- W2130767568 cites W2165700542 @default.
- W2130767568 cites W2167959216 @default.
- W2130767568 cites W2168547770 @default.
- W2130767568 cites W2168895735 @default.
- W2130767568 doi "https://doi.org/10.1210/en.2014-1404" @default.
- W2130767568 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25105783" @default.
- W2130767568 hasPublicationYear "2014" @default.
- W2130767568 type Work @default.
- W2130767568 sameAs 2130767568 @default.
- W2130767568 citedByCount "39" @default.
- W2130767568 countsByYear W21307675682015 @default.
- W2130767568 countsByYear W21307675682016 @default.
- W2130767568 countsByYear W21307675682017 @default.
- W2130767568 countsByYear W21307675682018 @default.
- W2130767568 countsByYear W21307675682019 @default.
- W2130767568 countsByYear W21307675682020 @default.
- W2130767568 countsByYear W21307675682021 @default.
- W2130767568 countsByYear W21307675682022 @default.
- W2130767568 countsByYear W21307675682023 @default.
- W2130767568 crossrefType "journal-article" @default.
- W2130767568 hasAuthorship W2130767568A5006173115 @default.
- W2130767568 hasAuthorship W2130767568A5008384624 @default.
- W2130767568 hasAuthorship W2130767568A5018129234 @default.
- W2130767568 hasBestOaLocation W21307675681 @default.
- W2130767568 hasConcept C104317684 @default.
- W2130767568 hasConcept C121608353 @default.
- W2130767568 hasConcept C126322002 @default.
- W2130767568 hasConcept C127716648 @default.
- W2130767568 hasConcept C134018914 @default.
- W2130767568 hasConcept C137487509 @default.
- W2130767568 hasConcept C145103041 @default.
- W2130767568 hasConcept C150194340 @default.
- W2130767568 hasConcept C16685009 @default.
- W2130767568 hasConcept C190727270 @default.
- W2130767568 hasConcept C2776166826 @default.
- W2130767568 hasConcept C2778324911 @default.
- W2130767568 hasConcept C2778486617 @default.
- W2130767568 hasConcept C2780753755 @default.
- W2130767568 hasConcept C2781471917 @default.
- W2130767568 hasConcept C41091548 @default.
- W2130767568 hasConcept C530470458 @default.
- W2130767568 hasConcept C54355233 @default.
- W2130767568 hasConcept C63405245 @default.
- W2130767568 hasConcept C71924100 @default.
- W2130767568 hasConcept C86803240 @default.
- W2130767568 hasConceptScore W2130767568C104317684 @default.
- W2130767568 hasConceptScore W2130767568C121608353 @default.
- W2130767568 hasConceptScore W2130767568C126322002 @default.
- W2130767568 hasConceptScore W2130767568C127716648 @default.
- W2130767568 hasConceptScore W2130767568C134018914 @default.