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• W2130779328 endingPage "10952" @default.
• W2130779328 startingPage "10944" @default.
• W2130779328 abstract "Abstract We have synthesized a new macromolecular architecture, (PAMAM)‐CD 8 , which consists of eight β‐cyclodextrin units (β‐CD) attached to a generation 1 poly(amidoamine) (PAMAM) dendrimer through a disulfide bond, which can be cleaved under reducing conditions. This system shows a pronounced hosting capability towards Gd III chelates functionalized with hydrophobic groups, thus leading to well‐defined supramolecular adducts. 1 H NMR relaxometric investigations were carried out to follow the formation of adducts with three Gd III chelates based on the ligand architectures of 6‐amino‐6‐methylperhydro‐1,4‐diazepinetetraacetic acid (AAZTA) or 1,4,7,10‐tetraazacyclododecane‐1,4,7,10‐tetraacetic acid (DOTA) suitably functionalized with benzyl or adamantyl (Ad) pendant groups. In particular, the ditopic complex composed of two AAZTA chelating units connected to a central aromatic ring that bears an adamantyl group showed a strong affinity (ca. 10 6 M −1 ) for the CD units of the dendrimer, which is two orders of magnitude higher than toward human serum albumin (HSA). Remarkable relaxivity enhancements (i.e., up to 71 % at 1 T and 25 °C) were observed upon the formation of the macromolecular host–guest adducts due to a decrease in the molecular tumbling rate and fast water‐exchange. Reduction experiments and competition studies between the paramagnetic dendrimer and HSA were carried out by relaxometric techniques. The results show that the metal complexes are not displaced by the protein, thus suggesting that this novel macromolecular probe is potentially suitable for applications in vivo." @default.
• W2130779328 created "2016-06-24" @default.
• W2130779328 creator A5039905156 @default.
• W2130779328 creator A5079933914 @default.
• W2130779328 creator A5089530145 @default.
• W2130779328 date "2014-05-14" @default.
• W2130779328 modified "2023-09-25" @default.
• W2130779328 title "Dendrimeric β-Cyclodextrin/Gd^IIIChelate Supramolecular Host-Guest Adducts as High-Relaxivity MRI Probes" @default.
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• W2130779328 doi "https://doi.org/10.1002/chem.201402418" @default.
• W2130779328 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24827137" @default.
• W2130779328 hasPublicationYear "2014" @default.
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