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• W2130796878 abstract "<h3>Abstract</h3> To define the cell populations in rheumatoid arthritis (RA) driving joint inflammation, we applied single-cell RNA-seq (scRNA-seq), mass cytometry, bulk RNA-seq, and flow cytometry to sorted T cells, B cells, monocytes, and fibroblasts from 51 synovial tissue RA and osteoarthritis (OA) patient samples. Utilizing an integrated computational strategy based on canonical correlation analysis to 5,452 scRNA-seq profiles, we identified 18 unique cell populations. Combining mass cytometry and transcriptomics together revealed cell states expanded in RA synovia: <i>THY1</i>⁺<i>HLA</i>^<i>high</i> sublining fibroblasts (OR=33.8), <i>IL1B</i>⁺ pro-inflammatory monocytes (OR=7.8), <i>CD11c</i>⁺<i>T-bet</i>⁺ autoimmune-associated B cells (OR=5.7), and <i>PD-1</i>⁺Tph/Tfh (OR=3.0). We also defined CD8⁺ T cell subsets characterized by <i>GZMK</i>⁺, <i>GZMB</i>⁺, and <i>GNLY</i>⁺ expression. Using bulk and single-cell data, we mapped inflammatory mediators to source cell populations, for example attributing <i>IL6</i> production to <i>THY1</i>⁺<i>HLA</i>^<i>high</i> fibroblasts and naïve B cells, and <i>IL1B</i> to pro-inflammatory monocytes. These populations are potentially key mediators of RA pathogenesis." @default.
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• W2130796878 date "2007-04-01" @default.
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• W2130796878 title "Comparison of 1 and 2 weeks of omeprazole, amoxicillin and clarithromycin treatment for Helicobacter pylori eradication: the HYPER Study" @default.
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• W2130796878 doi "https://doi.org/10.1136/gut.2006.102269" @default.
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