Matches in SemOpenAlex for { <https://semopenalex.org/work/W2130800855> ?p ?o ?g. }
- W2130800855 endingPage "926" @default.
- W2130800855 startingPage "918" @default.
- W2130800855 abstract "The prototypic second messenger cyclic AMP (cAMP) is essential for controlling cellular metabolism, including glucose and lipid homeostasis. In mammals, the majority of cAMP functions are mediated by cAMP-dependent protein kinase (PKA) and exchange proteins directly activated by cAMP (Epacs). To explore the physiological functions of Epac1, we generated Epac1 knockout mice. Here we report that Epac1 null mutants have reduced white adipose tissue and reduced plasma leptin levels but display heightened leptin sensitivity. Epac1-deficient mice are more resistant to high-fat diet-induced obesity, hyperleptinemia, and glucose intolerance. Furthermore, pharmacological inhibition of Epac by use of an Epac-specific inhibitor reduces plasma leptin levels in vivo and enhances leptin signaling in organotypic hypothalamic slices. Taken together, our results demonstrate that Epac1 plays an important role in regulating adiposity and energy balance." @default.
- W2130800855 created "2016-06-24" @default.
- W2130800855 creator A5031074359 @default.
- W2130800855 creator A5031147990 @default.
- W2130800855 creator A5034472419 @default.
- W2130800855 creator A5048763123 @default.
- W2130800855 creator A5053527731 @default.
- W2130800855 creator A5057596624 @default.
- W2130800855 creator A5061675864 @default.
- W2130800855 creator A5063859389 @default.
- W2130800855 creator A5064997314 @default.
- W2130800855 creator A5068722887 @default.
- W2130800855 creator A5072715016 @default.
- W2130800855 creator A5080619609 @default.
- W2130800855 creator A5084119638 @default.
- W2130800855 creator A5088448322 @default.
- W2130800855 creator A5089402611 @default.
- W2130800855 date "2013-03-01" @default.
- W2130800855 modified "2023-10-14" @default.
- W2130800855 title "Enhanced Leptin Sensitivity, Reduced Adiposity, and Improved Glucose Homeostasis in Mice Lacking Exchange Protein Directly Activated by Cyclic AMP Isoform 1" @default.
- W2130800855 cites W1631449371 @default.
- W2130800855 cites W1885709862 @default.
- W2130800855 cites W1900852307 @default.
- W2130800855 cites W1923807681 @default.
- W2130800855 cites W1959394985 @default.
- W2130800855 cites W1974747739 @default.
- W2130800855 cites W1975200746 @default.
- W2130800855 cites W1983286754 @default.
- W2130800855 cites W1988909797 @default.
- W2130800855 cites W1996683094 @default.
- W2130800855 cites W2003867612 @default.
- W2130800855 cites W2017157484 @default.
- W2130800855 cites W2019963667 @default.
- W2130800855 cites W2022430914 @default.
- W2130800855 cites W2024734221 @default.
- W2130800855 cites W2041872947 @default.
- W2130800855 cites W2042621509 @default.
- W2130800855 cites W2043625750 @default.
- W2130800855 cites W2043951178 @default.
- W2130800855 cites W2049847654 @default.
- W2130800855 cites W2051187742 @default.
- W2130800855 cites W2052743140 @default.
- W2130800855 cites W2065622820 @default.
- W2130800855 cites W2069584884 @default.
- W2130800855 cites W2071839617 @default.
- W2130800855 cites W2078037416 @default.
- W2130800855 cites W2079053528 @default.
- W2130800855 cites W2080324769 @default.
- W2130800855 cites W2084548757 @default.
- W2130800855 cites W2088666203 @default.
- W2130800855 cites W2098593394 @default.
- W2130800855 cites W2103270369 @default.
- W2130800855 cites W2104050631 @default.
- W2130800855 cites W2105987351 @default.
- W2130800855 cites W2111232488 @default.
- W2130800855 cites W2116843182 @default.
- W2130800855 cites W2118743996 @default.
- W2130800855 cites W2123641842 @default.
- W2130800855 cites W2125510262 @default.
- W2130800855 cites W2127071047 @default.
- W2130800855 cites W2129221666 @default.
- W2130800855 cites W2130166672 @default.
- W2130800855 cites W2136387838 @default.
- W2130800855 cites W2137137048 @default.
- W2130800855 cites W2143563119 @default.
- W2130800855 cites W2147417182 @default.
- W2130800855 cites W2147788805 @default.
- W2130800855 cites W2151172917 @default.
- W2130800855 cites W2153618088 @default.
- W2130800855 cites W2153816623 @default.
- W2130800855 cites W2158569927 @default.
- W2130800855 cites W2171241069 @default.
- W2130800855 cites W2313030845 @default.
- W2130800855 cites W2334337188 @default.
- W2130800855 doi "https://doi.org/10.1128/mcb.01227-12" @default.
- W2130800855 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3623083" @default.
- W2130800855 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23263987" @default.
- W2130800855 hasPublicationYear "2013" @default.
- W2130800855 type Work @default.
- W2130800855 sameAs 2130800855 @default.
- W2130800855 citedByCount "75" @default.
- W2130800855 countsByYear W21308008552013 @default.
- W2130800855 countsByYear W21308008552014 @default.
- W2130800855 countsByYear W21308008552015 @default.
- W2130800855 countsByYear W21308008552016 @default.
- W2130800855 countsByYear W21308008552017 @default.
- W2130800855 countsByYear W21308008552018 @default.
- W2130800855 countsByYear W21308008552019 @default.
- W2130800855 countsByYear W21308008552020 @default.
- W2130800855 countsByYear W21308008552021 @default.
- W2130800855 countsByYear W21308008552022 @default.
- W2130800855 countsByYear W21308008552023 @default.
- W2130800855 crossrefType "journal-article" @default.
- W2130800855 hasAuthorship W2130800855A5031074359 @default.
- W2130800855 hasAuthorship W2130800855A5031147990 @default.
- W2130800855 hasAuthorship W2130800855A5034472419 @default.
- W2130800855 hasAuthorship W2130800855A5048763123 @default.
- W2130800855 hasAuthorship W2130800855A5053527731 @default.