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• W2130804510 abstract "Many biochemical factors regulating progenitor cell differentiation have been examined in detail; however, the role of the local mechanical environment on stem cell fate has only recently been investigated. In this study, we examined whether oscillatory fluid flow, an exogenous mechanical signal within bone, regulates osteogenic, adipogenic or chondrogenic differentiation of C3H10T1/2 murine mesenchymal stem cells by measuring Runx2, PPARγ and SOX9 gene expression, respectively. Furthermore, we hypothesized that the small GTPase RhoA and isometric tension within the actin cytoskeleton are essential in flow-induced differentiation. We found that oscillatory fluid flow induces the upregulation of Runx2, Sox9 and PPARγ, indicating that it has the potential to regulate transcription factors involved in multiple unique lineage pathways. Furthermore, we demonstrate that the small GTPase RhoA and its effector protein ROCKII regulate fluid-flow-induced osteogenic differentiation. Additionally, activated RhoA and fluid flow have an additive effect on Runx2 expression. Finally, we show RhoA activation and actin tension are negative regulators of both adipogenic and chondrogenic differentiation. However, an intact, dynamic actin cytoskeleton under tension is necessary for flow-induced gene expression." @default.
• W2130804510 created "2016-06-24" @default.
• W2130804510 creator A5014169015 @default.
• W2130804510 creator A5019094352 @default.
• W2130804510 creator A5069272338 @default.
• W2130804510 creator A5086137850 @default.
• W2130804510 date "2009-02-15" @default.
• W2130804510 modified "2023-10-14" @default.
• W2130804510 title "Mechanically induced osteogenic differentiation – the role of RhoA, ROCKII and cytoskeletal dynamics" @default.
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• W2130804510 doi "https://doi.org/10.1242/jcs.036293" @default.
• W2130804510 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2714434" @default.
• W2130804510 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19174467" @default.
• W2130804510 hasPublicationYear "2009" @default.
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