FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2130809733> ?p ?o ?g. }

• W2130809733 endingPage "6449" @default.
• W2130809733 startingPage "6442" @default.
• W2130809733 abstract "The CpG island of GADD45G was identified as a target sequence during the identification of hypermethylated genes using methylation-sensitive representational difference analysis combined with 5-aza-2'-deoxycytidine demethylation. Located at the commonly deleted region 9q22, GADD45G is a member of the DNA damage-inducible gene family. In response to stress shock, GADD45G inhibits cell growth and induces apoptosis. Same as other GADD45 members, GADD45G is ubiquitously expressed in all normal adult and fetal tissues. However, its transcriptional silencing or down-regulation and promoter hypermethylation were frequently detected in tumor cell lines, including 11 of 13 (85%) non-Hodgkin's lymphoma, 3 of 6 (50%) Hodgkin's lymphoma, 8 of 11 (73%) nasopharyngeal carcinoma, 2 of 4 (50%) cervical carcinoma, 5 of 17 (29%) esophageal carcinoma, and 2 of 5 (40%) lung carcinoma and other cell lines but not in any immortalized normal epithelial cell line, normal tissue, or peripheral blood mononuclear cells. The silencing of GADD45G could be reversed by 5-aza-2'-deoxycytidine or genetic double knockout of DNMT1 and DNMT3B, indicating a direct epigenetic mechanism. Aberrant methylation was further frequently detected in primary lymphomas although less frequently in primary carcinomas. Only one single sequence change in the coding region was detected in 1 of 25 cell lines examined, indicating that genetic inactivation of GADD45G is very rare. GADD45G could be induced by heat shock or UV irradiation in unmethylated cell lines; however, this stress response was abolished when its promoter becomes hypermethylated. Ectopic expression of GADD45G strongly suppressed tumor cell growth and colony formation in silenced cell lines. These results show that GADD45G can act as a functional new-age tumor suppressor but being frequently inactivated epigenetically in multiple tumors." @default.
• W2130809733 created "2016-06-24" @default.
• W2130809733 creator A5015088500 @default.
• W2130809733 creator A5017842948 @default.
• W2130809733 creator A5032588771 @default.
• W2130809733 creator A5036545021 @default.
• W2130809733 creator A5042073138 @default.
• W2130809733 creator A5046701637 @default.
• W2130809733 creator A5068593672 @default.
• W2130809733 creator A5073387841 @default.
• W2130809733 date "2005-09-15" @default.
• W2130809733 modified "2023-10-16" @default.
• W2130809733 title "The Stress-Responsive Gene <i>GADD45G</i> Is a Functional Tumor Suppressor, with Its Response to Environmental Stresses Frequently Disrupted Epigenetically in Multiple Tumors" @default.
• W2130809733 cites W1504303645 @default.
• W2130809733 cites W1596182601 @default.
• W2130809733 cites W1753716921 @default.
• W2130809733 cites W1861749169 @default.
• W2130809733 cites W1967725040 @default.
• W2130809733 cites W1976708584 @default.
• W2130809733 cites W1977112045 @default.
• W2130809733 cites W1987615161 @default.
• W2130809733 cites W2005682191 @default.
• W2130809733 cites W2013276620 @default.
• W2130809733 cites W2018407799 @default.
• W2130809733 cites W2035361112 @default.
• W2130809733 cites W2037920286 @default.
• W2130809733 cites W2045773238 @default.
• W2130809733 cites W204961263 @default.
• W2130809733 cites W2051772772 @default.
• W2130809733 cites W2054823635 @default.
• W2130809733 cites W2055471936 @default.
• W2130809733 cites W2065445811 @default.
• W2130809733 cites W2068394634 @default.
• W2130809733 cites W2083555035 @default.
• W2130809733 cites W2085871516 @default.
• W2130809733 cites W2093188241 @default.
• W2130809733 cites W2093311838 @default.
• W2130809733 cites W2116599482 @default.
• W2130809733 cites W2124970384 @default.
• W2130809733 cites W2136795378 @default.
• W2130809733 cites W2149778428 @default.
• W2130809733 cites W2154891376 @default.
• W2130809733 cites W2323100652 @default.
• W2130809733 doi "https://doi.org/10.1158/1078-0432.ccr-05-0267" @default.
• W2130809733 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16166418" @default.
• W2130809733 hasPublicationYear "2005" @default.
• W2130809733 type Work @default.
• W2130809733 sameAs 2130809733 @default.
• W2130809733 citedByCount "193" @default.
• W2130809733 countsByYear W21308097332012 @default.
• W2130809733 countsByYear W21308097332013 @default.
• W2130809733 countsByYear W21308097332014 @default.
• W2130809733 countsByYear W21308097332015 @default.
• W2130809733 countsByYear W21308097332016 @default.
• W2130809733 countsByYear W21308097332017 @default.
• W2130809733 countsByYear W21308097332018 @default.
• W2130809733 countsByYear W21308097332019 @default.
• W2130809733 countsByYear W21308097332020 @default.
• W2130809733 countsByYear W21308097332021 @default.
• W2130809733 countsByYear W21308097332022 @default.
• W2130809733 countsByYear W21308097332023 @default.
• W2130809733 crossrefType "journal-article" @default.
• W2130809733 hasAuthorship W2130809733A5015088500 @default.
• W2130809733 hasAuthorship W2130809733A5017842948 @default.
• W2130809733 hasAuthorship W2130809733A5032588771 @default.
• W2130809733 hasAuthorship W2130809733A5036545021 @default.
• W2130809733 hasAuthorship W2130809733A5042073138 @default.
• W2130809733 hasAuthorship W2130809733A5046701637 @default.
• W2130809733 hasAuthorship W2130809733A5068593672 @default.
• W2130809733 hasAuthorship W2130809733A5073387841 @default.
• W2130809733 hasConcept C104317684 @default.
• W2130809733 hasConcept C119056186 @default.
• W2130809733 hasConcept C121608353 @default.
• W2130809733 hasConcept C150194340 @default.
• W2130809733 hasConcept C153911025 @default.
• W2130809733 hasConcept C175211621 @default.
• W2130809733 hasConcept C190727270 @default.
• W2130809733 hasConcept C2778264664 @default.
• W2130809733 hasConcept C33288867 @default.
• W2130809733 hasConcept C41091548 @default.
• W2130809733 hasConcept C502942594 @default.
• W2130809733 hasConcept C54355233 @default.
• W2130809733 hasConcept C555283112 @default.
• W2130809733 hasConcept C81885089 @default.
• W2130809733 hasConcept C86803240 @default.
• W2130809733 hasConcept C97037327 @default.
• W2130809733 hasConceptScore W2130809733C104317684 @default.
• W2130809733 hasConceptScore W2130809733C119056186 @default.
• W2130809733 hasConceptScore W2130809733C121608353 @default.
• W2130809733 hasConceptScore W2130809733C150194340 @default.
• W2130809733 hasConceptScore W2130809733C153911025 @default.
• W2130809733 hasConceptScore W2130809733C175211621 @default.
• W2130809733 hasConceptScore W2130809733C190727270 @default.
• W2130809733 hasConceptScore W2130809733C2778264664 @default.
• W2130809733 hasConceptScore W2130809733C33288867 @default.
• W2130809733 hasConceptScore W2130809733C41091548 @default.
• W2130809733 hasConceptScore W2130809733C502942594 @default.
• W2130809733 hasConceptScore W2130809733C54355233 @default.

• next