FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2130825384> ?p ?o ?g. }

• W2130825384 endingPage "5074" @default.
• W2130825384 startingPage "5065" @default.
• W2130825384 abstract "ABSTRACT Cruzipain, the major cysteinyl proteinase of Trypanosoma cruzi , is expressed by all developmental forms and strains of the parasite and stimulates potent humoral and cellular immune responses during infection in both humans and mice. This information suggested that cruzipain could be used to develop an effective T. cruzi vaccine. To study whether cruzipain-specific T cells could inhibit T. cruzi intracellular replication, we generated cruzipain-reactive CD4 + Th1 cell lines. These T cells produced large amounts of gamma interferon when cocultured with infected macrophages, resulting in NO production and decreased intracellular parasite replication. To study the protective effects in vivo of cruzipain-specific Th1 responses against systemic T. cruzi challenges, we immunized mice with recombinant cruzipain plus interleukin 12 (IL-12) and a neutralizing anti-IL-4 MAb. These immunized mice developed potent cruzipain-specific memory Th1 cell responses and were significantly protected against normally lethal systemic T. cruzi challenges. Although cruzipain-specific Th1 responses were associated with T. cruzi protective immunity in vitro and in vivo, adoptive transfer of cruzipain-specific Th1 cells alone did not protect BALB/c histocompatible mice, indicating that additional immune mechanisms are important for cruzipain-specific immunity. To study whether cruzipain could induce mucosal immune responses relevant for vaccine development, we prepared recombinant attenuated Salmonella enterica serovar Typhimurium vaccines expressing cruzipain. BALB/c mice immunized with salmonella expressing cruzipain were significantly protected against T. cruzi mucosal infection. Overall, these data indicate that cruzipain is an important T. cruzi vaccine candidate and that protective T. cruzi vaccines will need to induce more than CD4 + Th1 cells alone." @default.
• W2130825384 created "2016-06-24" @default.
• W2130825384 creator A5000464921 @default.
• W2130825384 creator A5029815230 @default.
• W2130825384 creator A5044344943 @default.
• W2130825384 creator A5056534752 @default.
• W2130825384 creator A5074581391 @default.
• W2130825384 date "2002-09-01" @default.
• W2130825384 modified "2023-10-16" @default.
• W2130825384 title "Cruzipain Induces Both Mucosal and Systemic Protection against <i>Trypanosoma cruzi</i> in Mice" @default.
• W2130825384 cites W1549352256 @default.
• W2130825384 cites W1726936532 @default.
• W2130825384 cites W1787453492 @default.
• W2130825384 cites W1870411326 @default.
• W2130825384 cites W1965899188 @default.
• W2130825384 cites W1971853331 @default.
• W2130825384 cites W1972000677 @default.
• W2130825384 cites W1974355562 @default.
• W2130825384 cites W1974914449 @default.
• W2130825384 cites W1983516462 @default.
• W2130825384 cites W1990802251 @default.
• W2130825384 cites W1993995415 @default.
• W2130825384 cites W1996985885 @default.
• W2130825384 cites W2005287646 @default.
• W2130825384 cites W2013930187 @default.
• W2130825384 cites W2018466824 @default.
• W2130825384 cites W2025627503 @default.
• W2130825384 cites W2031501484 @default.
• W2130825384 cites W2037061225 @default.
• W2130825384 cites W2039191904 @default.
• W2130825384 cites W2040061925 @default.
• W2130825384 cites W2042129019 @default.
• W2130825384 cites W2058877270 @default.
• W2130825384 cites W2062096354 @default.
• W2130825384 cites W2062472841 @default.
• W2130825384 cites W2071583406 @default.
• W2130825384 cites W2072652751 @default.
• W2130825384 cites W2074271466 @default.
• W2130825384 cites W2076896267 @default.
• W2130825384 cites W2083410935 @default.
• W2130825384 cites W209288036 @default.
• W2130825384 cites W2095399894 @default.
• W2130825384 cites W2095835949 @default.
• W2130825384 cites W2113110175 @default.
• W2130825384 cites W2124542225 @default.
• W2130825384 cites W2128720093 @default.
• W2130825384 cites W2133101176 @default.
• W2130825384 cites W2134917414 @default.
• W2130825384 cites W2137186924 @default.
• W2130825384 cites W2137586571 @default.
• W2130825384 cites W2145336455 @default.
• W2130825384 cites W2159923852 @default.
• W2130825384 cites W2243701891 @default.
• W2130825384 cites W2265581766 @default.
• W2130825384 cites W4232295453 @default.
• W2130825384 cites W4254632591 @default.
• W2130825384 doi "https://doi.org/10.1128/iai.70.9.5065-5074.2002" @default.
• W2130825384 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/128245" @default.
• W2130825384 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12183554" @default.
• W2130825384 hasPublicationYear "2002" @default.
• W2130825384 type Work @default.
• W2130825384 sameAs 2130825384 @default.
• W2130825384 citedByCount "80" @default.
• W2130825384 countsByYear W21308253842012 @default.
• W2130825384 countsByYear W21308253842013 @default.
• W2130825384 countsByYear W21308253842014 @default.
• W2130825384 countsByYear W21308253842015 @default.
• W2130825384 countsByYear W21308253842016 @default.
• W2130825384 countsByYear W21308253842020 @default.
• W2130825384 countsByYear W21308253842021 @default.
• W2130825384 countsByYear W21308253842022 @default.
• W2130825384 countsByYear W21308253842023 @default.
• W2130825384 crossrefType "journal-article" @default.
• W2130825384 hasAuthorship W2130825384A5000464921 @default.
• W2130825384 hasAuthorship W2130825384A5029815230 @default.
• W2130825384 hasAuthorship W2130825384A5044344943 @default.
• W2130825384 hasAuthorship W2130825384A5056534752 @default.
• W2130825384 hasAuthorship W2130825384A5074581391 @default.
• W2130825384 hasBestOaLocation W21308253841 @default.
• W2130825384 hasConcept C136764020 @default.
• W2130825384 hasConcept C159047783 @default.
• W2130825384 hasConcept C203014093 @default.
• W2130825384 hasConcept C2776548049 @default.
• W2130825384 hasConcept C2777625466 @default.
• W2130825384 hasConcept C3017875465 @default.
• W2130825384 hasConcept C41008148 @default.
• W2130825384 hasConcept C71928629 @default.
• W2130825384 hasConcept C86803240 @default.
• W2130825384 hasConcept C8891405 @default.
• W2130825384 hasConceptScore W2130825384C136764020 @default.
• W2130825384 hasConceptScore W2130825384C159047783 @default.
• W2130825384 hasConceptScore W2130825384C203014093 @default.
• W2130825384 hasConceptScore W2130825384C2776548049 @default.
• W2130825384 hasConceptScore W2130825384C2777625466 @default.
• W2130825384 hasConceptScore W2130825384C3017875465 @default.
• W2130825384 hasConceptScore W2130825384C41008148 @default.
• W2130825384 hasConceptScore W2130825384C71928629 @default.
• W2130825384 hasConceptScore W2130825384C86803240 @default.

• next