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• W2130833596 abstract "Objective— Cyclooxygenase (COX)-2 is a key regulatory enzyme in the synthesis of prostanoids associated with trauma and inflammation. We investigated the COX-2 gene for functional variants that may influence susceptibility to disease. Methods and Results— The promoter of COX-2 was screened for variants in healthy subjects by use of polymerase chain reaction-based methods. Promoter activity was investigated by using reporter expression experiments in human lung fibroblasts. Patients undergoing coronary artery bypass graft surgery, with measurements of plasma markers linked to COX-2 activity, were genotyped for association studies. A common COX-2 promoter variant, −765G>C, was found and shown to be carried by >25% of a group of healthy UK subjects. The −765C allele had significantly lower promoter activity compared with −765G, basally (28±3% lower, P <0.005) and in serum-stimulated cells (31±2% lower, P <0.005). In patients subjected to coronary artery bypass graft surgery, the magnitude of rise in levels of C-reactive protein (CRP) was strongly genotype dependent. Compared with −765G homozygotes, patients carrying the −765C allele had significantly lower plasma CRP levels at 1 to 4 days after surgery (14% lower at the peak of CRP levels on day 3, P <0.05 for all time points). Conclusions— For several acute and chronic inflammatory diseases, −765G>C may influence the variability of response observed." @default.
• W2130833596 created "2016-06-24" @default.
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• W2130833596 date "2002-10-01" @default.
• W2130833596 modified "2023-09-25" @default.
• W2130833596 title "Common Promoter Variant in Cyclooxygenase-2 Represses Gene Expression" @default.
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• W2130833596 doi "https://doi.org/10.1161/01.atv.0000030340.80207.c5" @default.
• W2130833596 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12377741" @default.
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