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- W2130838963 abstract "Serotonin (5-HT) has extensively been studied in the central and enteric nervous system. Altered levels of 5-HT play a role in many central nervous system (CNS) disorders and can be treated with specific 5-HT receptor agonists and antagonists. Interestingly, 95% of the bodies 5-HT is located outside central neuronal regions and in the intestine. The discovery of 5-HT secreting cells in the intestinal epithelium has resulted in a fruitful area of research that is focused on the function of intestinal epithelium-derived 5-HT.1 The subsequent discovery that 5-HT may play an important role in driving intestinal inflammation has generated interest in the potential of 5-HT antagonists for treatment of inflammatory bowel disease (IBD). However, side effects related to the important role of 5-HT in the enteric and central nervous system have precluded drug development in this field. In this issue of Gut , Margolis et al 2 use mouse models to demonstrate that it may be possible to selectively inhibit intestinal mucosal 5-HT signalling and suppress intestinal inflammation without such side effects. In the intestine, 5-HT is produced by a subset of enteroendrocrine cells called enterochromaffin (EC) …" @default.
- W2130838963 created "2016-06-24" @default.
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- W2130838963 date "2013-07-18" @default.
- W2130838963 modified "2023-09-27" @default.
- W2130838963 title "Selective inhibition of mucosal serotonin as treatment for IBD?" @default.
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- W2130838963 doi "https://doi.org/10.1136/gutjnl-2013-305283" @default.
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