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• W2130839453 abstract "Abstract Cyclin-dependent kinases (CDKs) regulate the progression of the cell cycle in eukaryotes. One of the major roles of CDK is to promote chromosomal DNA replication. However, how CDKs promote DNA replication has been a long-standing question, because all the essential CDK substrates in DNA replication have not been identified yet. Recently Sld2 and Sld3 were identified as essential substrates of CDKs in the initiation step of DNA replication in budding yeast. Moreover, bypass of their phosphorylations is sufficient to promote DNA replication. Phosphorylation of Sld2 and Sld3 by CDKs enhances the formation of complex(es) with a BRCT (BRCA1 C-Terminal)-containing replication protein, Dpb11. We further propose that multiple phosphorylation by CDKs controls this process in budding yeast. Even though Sld3 orthologues in multicellular eukaryotes have not been identified, similar complex formation and, therefore, a similar mechanism of initiation control might be employed in eukaryotes." @default.
• W2130839453 created "2016-06-24" @default.
• W2130839453 creator A5037697996 @default.
• W2130839453 creator A5081256427 @default.
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• W2130839453 date "2007-06-05" @default.
• W2130839453 modified "2023-09-26" @default.
• W2130839453 title "The role of CDK in the initiation step of DNA replication in eukaryotes" @default.
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• W2130839453 doi "https://doi.org/10.1186/1747-1028-2-16" @default.
• W2130839453 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1899495" @default.
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