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- W2130893040 abstract "Corticosteroid decreases neural cell production in the hippocampus,1 whereas antidepressants induce neurogenesis.2 The hippocampus is a brain region for memory formation. Decreased production of neurons in this region has a negative impact on cognitive function. We assessed the hypothesis that the neuro-damaging effect of high-dose corticosteroid on the hippocampus and subventricular zone (SVZ) could be reversed by administration of paroxetine—a selective serotonin reuptake inhibitor for treatment of depressive disorders. A rodent model was used to test the effect of paroxetine, corticosterone, and co-treatment of these two drugs on neurogenesis of the hippocampus and SVZ. In patients receiving steroid therapy, the neuroprotective effect of paroxetine suggests that administration of antidepressant could prevent deterioration of neuron production. This study aimed to investigate drug interactions of paroxetine, lithium, and corticosterone on the hippocampus and SVZ in terms of cell proliferation, dendritic morphology, neuronal survival, and molecular mechamisms, and whether selective serotonin reuptake inhibitor and lithium could exert protection against corticosteroneinduced neuron damage on the hippocampus and SVZ." @default.
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- W2130893040 date "2012-08-01" @default.
- W2130893040 modified "2023-10-01" @default.
- W2130893040 title "Neuroprotection in steroid therapy: a rodent model." @default.
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