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• W2130893314 abstract "Interferon (IFN)-associated psychiatric disorders can be managed without interruption to hepatitis C virus (HCV) treatment. The limited number of cases in the literature reporting psychotic depression as an adverse drug reaction to IFN resulted in discontinuation of HCV therapy. The author reports a case of a 49 year-old man with chronic HCV genotype 1a treated with pegylated interferon-alpha and ribavirin developing major depressive disorder with psychotic features. The patient was successfully treated with both an antidepressant and antipsychotic for this suspected IFN-associated adverse drug effect while continuing 12 months of uninterrupted HCV treatment and subsequently achieving sustained hepatitis C virological response. Although IFN can cause distressing psychiatric disturbances, appropriate treatment with psychotropic agents and careful monitoring allows patients to be maintained on a full course of HCV treatment. Keywords: Chronic hepatitis C virus, Pegylated interferon-alpha, Psychotic depression, Major depressive disorder, Psychosis, Antipsychotic" @default.
• W2130893314 created "2016-06-24" @default.
• W2130893314 creator A5042655750 @default.
• W2130893314 date "2011-01-01" @default.
• W2130893314 modified "2023-10-01" @default.
• W2130893314 title "Completion of Chronic Hepatitis C Virus Treatment in Interferon-Induced Major Depressive Disorder with Psychotic Features" @default.
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• W2130893314 doi "https://doi.org/10.4306/pi.2011.8.4.381" @default.
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