Matches in SemOpenAlex for { <https://semopenalex.org/work/W2130894493> ?p ?o ?g. }
- W2130894493 endingPage "2244" @default.
- W2130894493 startingPage "2223" @default.
- W2130894493 abstract "Mucoadhesive gelling systems based on chitosan and chitosan/β-glycerophosphate (β-GP) were developed in order to increase clotrimazole residence time in the vaginal cavity. Ex vivo mucoadhesiveness using porcine vaginal mucosa followed with mechanical, viscoelastic, and swelling properties of prepared hydrogels were evaluated. Drug-free, sterile, unmodified, and β-GP crosslinked chitosan were investigated for the in vitro cytotoxicity in CRL 2616 human vaginal mucosa cells using MTT assay, fluorescent microscopy, and flow cytometry analysis. Chitosan/β-GP hydrogels exhibited pseudoplastic and thixotropic properties. Ionic interaction between β-GP and chitosan improved mechanical properties of hydrogels in terms of hardness, cohesiveness, and compressibility. The hydrogels’ ability to interact with porcine vaginal mucosa (measured as force of detachment and work of adhesion) was comparable to those obtained with reference mucoadhesive gel Replens™. Surprisingly, greater mucoadhesive properties were noticed for chitosan/β-GP hydrogels. The cytotoxic effect of unmodified and β-GP crosslinked chitosan was hardly affected by chitosan molecular weight, exhibited mainly through inducing apoptosis, and was found to be significantly lower in the presence of chitosan/β-GP. Furthermore, the higher amount of β-GP was used to crosslink chitosan, the lower cytotoxic effect was observed." @default.
- W2130894493 created "2016-06-24" @default.
- W2130894493 creator A5006583673 @default.
- W2130894493 creator A5021725456 @default.
- W2130894493 creator A5043147489 @default.
- W2130894493 creator A5051579907 @default.
- W2130894493 creator A5058687933 @default.
- W2130894493 creator A5087262729 @default.
- W2130894493 date "2015-11-04" @default.
- W2130894493 modified "2023-10-08" @default.
- W2130894493 title "The Effect of β-Glycerophosphate Crosslinking on Chitosan Cytotoxicity and Properties of Hydrogels for Vaginal Application" @default.
- W2130894493 cites W1573113422 @default.
- W2130894493 cites W1771885577 @default.
- W2130894493 cites W1968484005 @default.
- W2130894493 cites W1975207418 @default.
- W2130894493 cites W1976147433 @default.
- W2130894493 cites W1976248881 @default.
- W2130894493 cites W1995175553 @default.
- W2130894493 cites W1997154876 @default.
- W2130894493 cites W2001828401 @default.
- W2130894493 cites W2001895546 @default.
- W2130894493 cites W2003235711 @default.
- W2130894493 cites W2015301858 @default.
- W2130894493 cites W2021742090 @default.
- W2130894493 cites W2028440673 @default.
- W2130894493 cites W2031038256 @default.
- W2130894493 cites W2034170334 @default.
- W2130894493 cites W2037096236 @default.
- W2130894493 cites W2041880062 @default.
- W2130894493 cites W2046886904 @default.
- W2130894493 cites W2050200989 @default.
- W2130894493 cites W2050931052 @default.
- W2130894493 cites W2061194327 @default.
- W2130894493 cites W2063110356 @default.
- W2130894493 cites W2063700817 @default.
- W2130894493 cites W2064338333 @default.
- W2130894493 cites W2065307591 @default.
- W2130894493 cites W2071059761 @default.
- W2130894493 cites W2071713533 @default.
- W2130894493 cites W2072695223 @default.
- W2130894493 cites W2073000545 @default.
- W2130894493 cites W2075913023 @default.
- W2130894493 cites W2076799931 @default.
- W2130894493 cites W2078532650 @default.
- W2130894493 cites W2079665323 @default.
- W2130894493 cites W2083056135 @default.
- W2130894493 cites W2085648623 @default.
- W2130894493 cites W2085877896 @default.
- W2130894493 cites W2086775219 @default.
- W2130894493 cites W2087247100 @default.
- W2130894493 cites W2087541092 @default.
- W2130894493 cites W2097737743 @default.
- W2130894493 cites W2111049932 @default.
- W2130894493 cites W2126191214 @default.
- W2130894493 cites W2128488279 @default.
- W2130894493 cites W2130218657 @default.
- W2130894493 cites W2131945662 @default.
- W2130894493 cites W2142634248 @default.
- W2130894493 cites W2143456833 @default.
- W2130894493 cites W2154899729 @default.
- W2130894493 cites W2158643446 @default.
- W2130894493 cites W2162099509 @default.
- W2130894493 cites W2166291746 @default.
- W2130894493 cites W2170101626 @default.
- W2130894493 cites W2322683909 @default.
- W2130894493 cites W2326030540 @default.
- W2130894493 cites W2946858441 @default.
- W2130894493 cites W41460561 @default.
- W2130894493 doi "https://doi.org/10.3390/polym7111510" @default.
- W2130894493 hasPublicationYear "2015" @default.
- W2130894493 type Work @default.
- W2130894493 sameAs 2130894493 @default.
- W2130894493 citedByCount "32" @default.
- W2130894493 countsByYear W21308944932016 @default.
- W2130894493 countsByYear W21308944932017 @default.
- W2130894493 countsByYear W21308944932018 @default.
- W2130894493 countsByYear W21308944932019 @default.
- W2130894493 countsByYear W21308944932020 @default.
- W2130894493 countsByYear W21308944932021 @default.
- W2130894493 countsByYear W21308944932022 @default.
- W2130894493 countsByYear W21308944932023 @default.
- W2130894493 crossrefType "journal-article" @default.
- W2130894493 hasAuthorship W2130894493A5006583673 @default.
- W2130894493 hasAuthorship W2130894493A5021725456 @default.
- W2130894493 hasAuthorship W2130894493A5043147489 @default.
- W2130894493 hasAuthorship W2130894493A5051579907 @default.
- W2130894493 hasAuthorship W2130894493A5058687933 @default.
- W2130894493 hasAuthorship W2130894493A5087262729 @default.
- W2130894493 hasBestOaLocation W21308944931 @default.
- W2130894493 hasConcept C108586683 @default.
- W2130894493 hasConcept C109316439 @default.
- W2130894493 hasConcept C13245373 @default.
- W2130894493 hasConcept C13965031 @default.
- W2130894493 hasConcept C159985019 @default.
- W2130894493 hasConcept C178790620 @default.
- W2130894493 hasConcept C185592680 @default.
- W2130894493 hasConcept C188027245 @default.
- W2130894493 hasConcept C192562407 @default.