Matches in SemOpenAlex for { <https://semopenalex.org/work/W2130897798> ?p ?o ?g. }
- W2130897798 endingPage "97" @default.
- W2130897798 startingPage "85" @default.
- W2130897798 abstract "ABSTRACT The association between extreme-prematurity births and intrauterine infection emphasizes the importance of understanding the host immune responses against uterine-invading microbes during early pregnancy to the prevention of preterm births. Listeria monocytogenes , a clinically relevant intracellular bacterium, has a predilection for replication at the maternofetal interface during pregnancy. Here, using mice carrying the recessive null osteopetrotic mutation in the colony-stimulating factor-1 (CSF-1) gene, we show that CSF-1-dependent macrophage functions are required for the maternal decidua immune responses against L. monocytogenes infections during early gestation in mice. In the absence of CSF-1, pregnant mice were more susceptible to uterine infection by L. monocytogenes ; their inability to control the expansion of colonized bacteria in the pregnant uterus led to decidual cell death, tissue disintegration, and resorption of the developing embryo. However, CSF-1-deficient mice were able to produce significant levels of both Th1 cytokines and neutrophil chemoattractants and to recruit neutrophils to the decidual tissue in response to Listeria infection. Depletion of macrophages in hormonally induced pseudopregnant mice resulted in higher uterine bacterial levels after L. monocytogenes infection. These data suggest that the anti- Listeria responses in the maternal decidual tissue are dependent on CSF-1-regulated macrophages." @default.
- W2130897798 created "2016-06-24" @default.
- W2130897798 creator A5005096654 @default.
- W2130897798 creator A5048433156 @default.
- W2130897798 creator A5073221843 @default.
- W2130897798 date "2009-01-01" @default.
- W2130897798 modified "2023-09-23" @default.
- W2130897798 title "Colony-Stimulating Factor-1-Dependent Macrophage Functions Regulate the Maternal Decidua Immune Responses against<i>Listeria monocytogenes</i>Infections during Early Gestation in Mice" @default.
- W2130897798 cites W132534127 @default.
- W2130897798 cites W1495081712 @default.
- W2130897798 cites W1534771310 @default.
- W2130897798 cites W1602437032 @default.
- W2130897798 cites W1606949166 @default.
- W2130897798 cites W1805424979 @default.
- W2130897798 cites W1972375527 @default.
- W2130897798 cites W1975656275 @default.
- W2130897798 cites W1975755498 @default.
- W2130897798 cites W1979514172 @default.
- W2130897798 cites W1980310807 @default.
- W2130897798 cites W1983895762 @default.
- W2130897798 cites W1989730434 @default.
- W2130897798 cites W1993093183 @default.
- W2130897798 cites W1993677761 @default.
- W2130897798 cites W2009550948 @default.
- W2130897798 cites W2020020415 @default.
- W2130897798 cites W2020640796 @default.
- W2130897798 cites W2022122015 @default.
- W2130897798 cites W2025162592 @default.
- W2130897798 cites W2025568822 @default.
- W2130897798 cites W2027509917 @default.
- W2130897798 cites W2033440580 @default.
- W2130897798 cites W2041138285 @default.
- W2130897798 cites W2043218957 @default.
- W2130897798 cites W2046555621 @default.
- W2130897798 cites W2048801137 @default.
- W2130897798 cites W2049165127 @default.
- W2130897798 cites W2057138015 @default.
- W2130897798 cites W2065871536 @default.
- W2130897798 cites W2068360183 @default.
- W2130897798 cites W2068871282 @default.
- W2130897798 cites W2069051729 @default.
- W2130897798 cites W2070437307 @default.
- W2130897798 cites W2087210742 @default.
- W2130897798 cites W2089262366 @default.
- W2130897798 cites W2089345298 @default.
- W2130897798 cites W2093502899 @default.
- W2130897798 cites W2100691180 @default.
- W2130897798 cites W2103663550 @default.
- W2130897798 cites W2103863906 @default.
- W2130897798 cites W2124446335 @default.
- W2130897798 cites W2133351125 @default.
- W2130897798 cites W2134955446 @default.
- W2130897798 cites W2138168133 @default.
- W2130897798 cites W2139535814 @default.
- W2130897798 cites W2144152742 @default.
- W2130897798 cites W2145375514 @default.
- W2130897798 cites W2148330408 @default.
- W2130897798 cites W2158401991 @default.
- W2130897798 cites W2166041794 @default.
- W2130897798 cites W2169930621 @default.
- W2130897798 cites W2171542849 @default.
- W2130897798 cites W2188419301 @default.
- W2130897798 cites W2326987869 @default.
- W2130897798 cites W2331780577 @default.
- W2130897798 cites W342912794 @default.
- W2130897798 cites W4238304450 @default.
- W2130897798 cites W4243140277 @default.
- W2130897798 cites W4250007760 @default.
- W2130897798 cites W2166630691 @default.
- W2130897798 doi "https://doi.org/10.1128/iai.01022-08" @default.
- W2130897798 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2612255" @default.
- W2130897798 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18852237" @default.
- W2130897798 hasPublicationYear "2009" @default.
- W2130897798 type Work @default.
- W2130897798 sameAs 2130897798 @default.
- W2130897798 citedByCount "28" @default.
- W2130897798 countsByYear W21308977982012 @default.
- W2130897798 countsByYear W21308977982013 @default.
- W2130897798 countsByYear W21308977982015 @default.
- W2130897798 countsByYear W21308977982016 @default.
- W2130897798 countsByYear W21308977982017 @default.
- W2130897798 countsByYear W21308977982018 @default.
- W2130897798 countsByYear W21308977982019 @default.
- W2130897798 countsByYear W21308977982020 @default.
- W2130897798 countsByYear W21308977982021 @default.
- W2130897798 countsByYear W21308977982022 @default.
- W2130897798 countsByYear W21308977982023 @default.
- W2130897798 crossrefType "journal-article" @default.
- W2130897798 hasAuthorship W2130897798A5005096654 @default.
- W2130897798 hasAuthorship W2130897798A5048433156 @default.
- W2130897798 hasAuthorship W2130897798A5073221843 @default.
- W2130897798 hasBestOaLocation W21308977981 @default.
- W2130897798 hasConcept C134018914 @default.
- W2130897798 hasConcept C172680121 @default.
- W2130897798 hasConcept C202751555 @default.
- W2130897798 hasConcept C203014093 @default.
- W2130897798 hasConcept C2776953305 @default.
- W2130897798 hasConcept C2777187800 @default.