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- W2130903977 abstract "Voltage-gated sodium channels (Nav) are essential for initiation and propagation of action potentials. Previous in vitro studies reported that exposure to the Nav toxins veratridine and α scorpion toxin cause persistent downregulation of Nav mRNA in vitro. However the mechanism of this downregulation is not well characterized. Here, we report that the type-II pyrethroid deltamethrin, which has a similar mechanism as these toxins, elicited an approximate 25% reduction in Nav 1.2 and Nav 1.3 mRNA in SK-N-AS cells. Deltamethrin-induced decreases of Nav mRNA were blocked with the Nav antagonist tetrodotoxin, demonstrating a primary role for interaction with Nav. Pre–treatment with the intracellular calcium chelator BAPTA-AM and the calpain inhibitor PD-150606 also prevented these decreases, identifying a role for intracellular calcium and calpain activation. Because alterations in Nav expression and function can result in neurotoxicity, additional studies are warranted to determine whether or not such effects occur in vivo." @default.
- W2130903977 created "2016-06-24" @default.
- W2130903977 creator A5021586993 @default.
- W2130903977 creator A5069416196 @default.
- W2130903977 date "2014-10-30" @default.
- W2130903977 modified "2023-09-26" @default.
- W2130903977 title "Role of Calcium and Calpain in the Downregulation of Voltage-Gated Sodium Channel Expression by the Pyrethroid Pesticide Deltamethrin" @default.
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- W2130903977 doi "https://doi.org/10.1002/jbt.21676" @default.
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