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- W2130906176 abstract "A 45-year-old male, diagnosed with plasma cell myeloma with an immunoglobulin A paraprotein of 26 g/l, underwent a bone marrow biopsy prior to commencement of bortezomib, dexamethasone and doxorubicin. This was on a background of monoclonal gammopathy of uncertain significance with extensive involvement of the liver with AL amyloid. Bone marrow trephine biopsy sections demonstrated that plasma cells constituted 50% of total nucleated cells. Large amounts of amyloid were present. Following chemotherapy no paraprotein was detected and repeat bone marrow sections demonstrated morphological remission associated with a significant reduction in amyloid deposition. However, amorphous salmon pink material was dispersed evenly throughout the sections, distorting the normal marrow architecture. The amorphous material stained positively for syndecan-1 (CD138) (top) and with Masson tri-colour stain for collagen (bottom). Accumulation of syndecan-1 within the extracellular matrix of the marrow most likely results from shedding of the molecule from the surface of myeloma cells. Soluble syndecan-1 is present at high levels in the serum of patients with plasma cell myeloma and has been demonstrated to be an indicator of poor prognosis. Because syndecan-1 can act to regulate the activity of heparan-binding growth factors, these reservoirs of syndecan-1 may play a critical role in promoting myeloma pathogenesis, or in regeneration of the tumour after chemotherapy. In particular, it has been shown that syndecan-1 mediates hepatocyte growth factor binding and promotes c-met signalling in myeloma cells. Heparanase is involved in the regulation of syndecan-1 gene (SDC1) expression and controls the production of soluble syndecan-1 in myeloma cell lines. High heparanase expression in bone marrow of patients with plasma cell myeloma has been associated with a shorter event-free and overall survival. Nothing to report." @default.
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- W2130906176 date "2010-07-12" @default.
- W2130906176 modified "2023-10-18" @default.
- W2130906176 title "CD138 shedding in plasma cell myeloma" @default.
- W2130906176 doi "https://doi.org/10.1111/j.1365-2141.2010.08203.x" @default.
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