FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2130918056> ?p ?o ?g. }

• W2130918056 endingPage "104" @default.
• W2130918056 startingPage "93" @default.
• W2130918056 abstract "Our laboratories have prepared a novel class of iron (Fe) chelators of the 2-pyridylcarboxaldehyde isonicotinoyl hydrazone (PCIH) class. This article will review the iron chelation efficacy of this series of chelators, both in cell culture and in animal models. Several PCIH analogs were shown to be effective at inducing iron mobilization and preventing iron uptake from the iron-transport protein, transferrin. Moreover, several of these ligands were effective at permeating the mitochondrion and inducing iron release. Studies in mice demonstrated that the PCIH analog, PCTH, was orally active and well tolerated by mice at doses ranging from 50 to 100 mg kg−1, twice daily (b.d.). A dose-dependent increase in fecal 59Fe excretion was observed in the PCTH-treated group. This level of iron excretion was similar to that found for the orally effective chelators, pyridoxal isonicotinoyl hydrazone (PIH) and deferiprone (L1). The PCIH group of ligands clearly has the potential for the treatment of β-thalassemia (thal) and Friedreich's Ataxia (FA)." @default.
• W2130918056 created "2016-06-24" @default.
• W2130918056 creator A5048968219 @default.
• W2130918056 creator A5055735150 @default.
• W2130918056 creator A5057319709 @default.
• W2130918056 creator A5061763563 @default.
• W2130918056 date "2006-01-01" @default.
• W2130918056 modified "2023-09-25" @default.
• W2130918056 title "PCTH: A Novel Orally Active Chelator for the Treatment of Iron Overload Disease" @default.
• W2130918056 cites W1497514444 @default.
• W2130918056 cites W1502461041 @default.
• W2130918056 cites W1514932744 @default.
• W2130918056 cites W1526693931 @default.
• W2130918056 cites W1584681190 @default.
• W2130918056 cites W1966702938 @default.
• W2130918056 cites W1979703805 @default.
• W2130918056 cites W1992125101 @default.
• W2130918056 cites W1995087031 @default.
• W2130918056 cites W2007991324 @default.
• W2130918056 cites W2022288325 @default.
• W2130918056 cites W2031773431 @default.
• W2130918056 cites W2055882158 @default.
• W2130918056 cites W2065071495 @default.
• W2130918056 cites W2088913243 @default.
• W2130918056 cites W2092224500 @default.
• W2130918056 cites W2094173166 @default.
• W2130918056 cites W2119241207 @default.
• W2130918056 cites W2167980905 @default.
• W2130918056 cites W2168013509 @default.
• W2130918056 cites W2171559922 @default.
• W2130918056 cites W4237791867 @default.
• W2130918056 doi "https://doi.org/10.1080/03630260500455367" @default.
• W2130918056 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16540421" @default.
• W2130918056 hasPublicationYear "2006" @default.
• W2130918056 type Work @default.
• W2130918056 sameAs 2130918056 @default.
• W2130918056 citedByCount "9" @default.
• W2130918056 countsByYear W21309180562012 @default.
• W2130918056 countsByYear W21309180562013 @default.
• W2130918056 countsByYear W21309180562015 @default.
• W2130918056 countsByYear W21309180562018 @default.
• W2130918056 countsByYear W21309180562022 @default.
• W2130918056 crossrefType "journal-article" @default.
• W2130918056 hasAuthorship W2130918056A5048968219 @default.
• W2130918056 hasAuthorship W2130918056A5055735150 @default.
• W2130918056 hasAuthorship W2130918056A5057319709 @default.
• W2130918056 hasAuthorship W2130918056A5061763563 @default.
• W2130918056 hasConcept C10146269 @default.
• W2130918056 hasConcept C126322002 @default.
• W2130918056 hasConcept C179104552 @default.
• W2130918056 hasConcept C185592680 @default.
• W2130918056 hasConcept C197404232 @default.
• W2130918056 hasConcept C22814914 @default.
• W2130918056 hasConcept C2776517179 @default.
• W2130918056 hasConcept C2776672577 @default.
• W2130918056 hasConcept C2777218474 @default.
• W2130918056 hasConcept C2777799968 @default.
• W2130918056 hasConcept C2780349576 @default.
• W2130918056 hasConcept C2781053155 @default.
• W2130918056 hasConcept C55493867 @default.
• W2130918056 hasConcept C71240020 @default.
• W2130918056 hasConcept C71924100 @default.
• W2130918056 hasConcept C98274493 @default.
• W2130918056 hasConceptScore W2130918056C10146269 @default.
• W2130918056 hasConceptScore W2130918056C126322002 @default.
• W2130918056 hasConceptScore W2130918056C179104552 @default.
• W2130918056 hasConceptScore W2130918056C185592680 @default.
• W2130918056 hasConceptScore W2130918056C197404232 @default.
• W2130918056 hasConceptScore W2130918056C22814914 @default.
• W2130918056 hasConceptScore W2130918056C2776517179 @default.
• W2130918056 hasConceptScore W2130918056C2776672577 @default.
• W2130918056 hasConceptScore W2130918056C2777218474 @default.
• W2130918056 hasConceptScore W2130918056C2777799968 @default.
• W2130918056 hasConceptScore W2130918056C2780349576 @default.
• W2130918056 hasConceptScore W2130918056C2781053155 @default.
• W2130918056 hasConceptScore W2130918056C55493867 @default.
• W2130918056 hasConceptScore W2130918056C71240020 @default.
• W2130918056 hasConceptScore W2130918056C71924100 @default.
• W2130918056 hasConceptScore W2130918056C98274493 @default.
• W2130918056 hasIssue "1" @default.
• W2130918056 hasLocation W21309180561 @default.
• W2130918056 hasLocation W21309180562 @default.
• W2130918056 hasOpenAccess W2130918056 @default.
• W2130918056 hasPrimaryLocation W21309180561 @default.
• W2130918056 hasRelatedWork W2044790639 @default.
• W2130918056 hasRelatedWork W2064828098 @default.
• W2130918056 hasRelatedWork W2094173166 @default.
• W2130918056 hasRelatedWork W2102907261 @default.
• W2130918056 hasRelatedWork W2118942391 @default.
• W2130918056 hasRelatedWork W2130918056 @default.
• W2130918056 hasRelatedWork W2139685175 @default.
• W2130918056 hasRelatedWork W2187575468 @default.
• W2130918056 hasRelatedWork W2397435675 @default.
• W2130918056 hasRelatedWork W2758699714 @default.
• W2130918056 hasVolume "30" @default.
• W2130918056 isParatext "false" @default.
• W2130918056 isRetracted "false" @default.
• W2130918056 magId "2130918056" @default.

• next