FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2130937946> ?p ?o ?g. }

• W2130937946 endingPage "293" @default.
• W2130937946 startingPage "287" @default.
• W2130937946 abstract "We previously reported that the proportion of large-size micronuclei (MN) can be a reliable parameter to discriminate aneugens from clastogens in the in vitro MN assay using Chinese hamster lung cells. The frequencies of polynuclear (PN) and mitotic (M) cells are also supposed to be useful parameters for the same purpose since they are known to be increased by aneugens. In the present study, we investigated whether morphological observations of the cell nucleus can be applied for the in vitro MN assay using the p53-competent human lymphoblastoid cell line, TK6 cells. Our present MN assay with six clastogens and six aneugens revealed that the frequencies of large-size MN or PN cells cannot distinguish aneugens from clastogens, while the frequencies of M cells can distinguish them, suggesting that the M-cell frequency is a recommended parameter to determine a mode of action for MN induction in the in vitro MN assay using TK6 cells. Our further investigation using p53-null mutant NH32 cells showed that the frequencies of large-size MN or PN cells induced by aneugen treatments were higher than those in TK6 cells but not by clastogen treatments. These findings suggest that p53 abrogation promotes the susceptibility for morphological changes in the nucleus to aneugens and that morphological observation of the cell nucleus including size-classifying MN counting could distinguish aneugens from clastogens in the MN assay using NH32 cells." @default.
• W2130937946 created "2016-06-24" @default.
• W2130937946 creator A5015239386 @default.
• W2130937946 creator A5017831409 @default.
• W2130937946 creator A5018809044 @default.
• W2130937946 creator A5023301597 @default.
• W2130937946 date "2011-10-31" @default.
• W2130937946 modified "2023-10-05" @default.
• W2130937946 title "Difference in susceptibility to morphological changes in the nucleus to aneugens between p53-competent and p53-abrogated lymphoblastoid cell lines (TK6 and NH32 cells) in the in vitro micronucleus assay" @default.
• W2130937946 cites W1966380833 @default.
• W2130937946 cites W1967331918 @default.
• W2130937946 cites W1974970143 @default.
• W2130937946 cites W1983338587 @default.
• W2130937946 cites W1990658681 @default.
• W2130937946 cites W1991736202 @default.
• W2130937946 cites W1997724861 @default.
• W2130937946 cites W2010647368 @default.
• W2130937946 cites W2016277572 @default.
• W2130937946 cites W2021905009 @default.
• W2130937946 cites W2023200988 @default.
• W2130937946 cites W2033511560 @default.
• W2130937946 cites W2033865457 @default.
• W2130937946 cites W2042667650 @default.
• W2130937946 cites W2056257023 @default.
• W2130937946 cites W2059613902 @default.
• W2130937946 cites W2069300266 @default.
• W2130937946 cites W2071152209 @default.
• W2130937946 cites W2077268247 @default.
• W2130937946 cites W2078801339 @default.
• W2130937946 cites W2099268087 @default.
• W2130937946 cites W2099682050 @default.
• W2130937946 cites W2100990262 @default.
• W2130937946 cites W2112560233 @default.
• W2130937946 cites W2134590240 @default.
• W2130937946 cites W2139718226 @default.
• W2130937946 cites W2148914308 @default.
• W2130937946 cites W2151613197 @default.
• W2130937946 cites W2154771600 @default.
• W2130937946 cites W2168757568 @default.
• W2130937946 cites W2575095704 @default.
• W2130937946 cites W2774928640 @default.
• W2130937946 doi "https://doi.org/10.1093/mutage/ger074" @default.
• W2130937946 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22042714" @default.
• W2130937946 hasPublicationYear "2011" @default.
• W2130937946 type Work @default.
• W2130937946 sameAs 2130937946 @default.
• W2130937946 citedByCount "5" @default.
• W2130937946 countsByYear W21309379462013 @default.
• W2130937946 countsByYear W21309379462016 @default.
• W2130937946 countsByYear W21309379462019 @default.
• W2130937946 countsByYear W21309379462022 @default.
• W2130937946 crossrefType "journal-article" @default.
• W2130937946 hasAuthorship W2130937946A5015239386 @default.
• W2130937946 hasAuthorship W2130937946A5017831409 @default.
• W2130937946 hasAuthorship W2130937946A5018809044 @default.
• W2130937946 hasAuthorship W2130937946A5023301597 @default.
• W2130937946 hasConcept C113842279 @default.
• W2130937946 hasConcept C141710004 @default.
• W2130937946 hasConcept C1491633281 @default.
• W2130937946 hasConcept C153911025 @default.
• W2130937946 hasConcept C178790620 @default.
• W2130937946 hasConcept C185592680 @default.
• W2130937946 hasConcept C202751555 @default.
• W2130937946 hasConcept C2777755551 @default.
• W2130937946 hasConcept C2778575167 @default.
• W2130937946 hasConcept C2780723820 @default.
• W2130937946 hasConcept C29730261 @default.
• W2130937946 hasConcept C36681516 @default.
• W2130937946 hasConcept C45080847 @default.
• W2130937946 hasConcept C54355233 @default.
• W2130937946 hasConcept C81885089 @default.
• W2130937946 hasConcept C86803240 @default.
• W2130937946 hasConcept C95444343 @default.
• W2130937946 hasConceptScore W2130937946C113842279 @default.
• W2130937946 hasConceptScore W2130937946C141710004 @default.
• W2130937946 hasConceptScore W2130937946C1491633281 @default.
• W2130937946 hasConceptScore W2130937946C153911025 @default.
• W2130937946 hasConceptScore W2130937946C178790620 @default.
• W2130937946 hasConceptScore W2130937946C185592680 @default.
• W2130937946 hasConceptScore W2130937946C202751555 @default.
• W2130937946 hasConceptScore W2130937946C2777755551 @default.
• W2130937946 hasConceptScore W2130937946C2778575167 @default.
• W2130937946 hasConceptScore W2130937946C2780723820 @default.
• W2130937946 hasConceptScore W2130937946C29730261 @default.
• W2130937946 hasConceptScore W2130937946C36681516 @default.
• W2130937946 hasConceptScore W2130937946C45080847 @default.
• W2130937946 hasConceptScore W2130937946C54355233 @default.
• W2130937946 hasConceptScore W2130937946C81885089 @default.
• W2130937946 hasConceptScore W2130937946C86803240 @default.
• W2130937946 hasConceptScore W2130937946C95444343 @default.
• W2130937946 hasIssue "3" @default.
• W2130937946 hasLocation W21309379461 @default.
• W2130937946 hasLocation W21309379462 @default.
• W2130937946 hasOpenAccess W2130937946 @default.
• W2130937946 hasPrimaryLocation W21309379461 @default.
• W2130937946 hasRelatedWork W1973283574 @default.
• W2130937946 hasRelatedWork W1987757902 @default.
• W2130937946 hasRelatedWork W2019318714 @default.

• next