Matches in SemOpenAlex for { <https://semopenalex.org/work/W2130942146> ?p ?o ?g. }
Showing items 1 to 95 of
95
with 100 items per page.
- W2130942146 endingPage "199" @default.
- W2130942146 startingPage "195" @default.
- W2130942146 abstract "Background: This study was conducted to determine the influence of MACC1 expression on chemotherapy sensitivity in human U251 glioblastoma cells. Materials and Methods: Expression of the MACC1 gene in 49 cases of human brain glioma was determined by quantitative real-time PCR. Silencing effects of RNA interference on MACC1 was detected by Western-blotting. Flow cytometry methods and methyl thiazolyl tetrazolium assay (MTT) were used to determine the apoptosis and growth inhibitory rates of the U251 cells with MACC1 silencing. before and after treatment with cisplatin (DDP). Results: MACC1 mRNA in gliomas was up-regulated remarkably, to 158.8% of that in peri-cancerous tissues (P<0.05). The siRNA-MACC1 could inhibit the expression of MACC1 protein significantly (p<0.05), associated with an increase in apoptosis rate from 2.57% to 5.39% in U251 cells and elevation of the growth inhibitory rate from 1.5% to 17.8% (p<0.05 for both). After treatment with DDP at various concentrations (1, 3, <TEX>$5{mu}g/ml$</TEX>), compared with control U251 cells, the apoptosis rate of MACC1-silenced U251 cells rose from 8.41%, 13.2% and 19.5% to 12.8%, 17.8% and 25.8%; the growth inhibitory rate increased from 16.2%, 19.3% and 24.5% to 23.7%, 28.4% and 36.3%. Conclusions: There is a notable relationship between over-expression of MACC1 and the characteristics of glioma cells. Silencing of MACC1 was found to enhance the apoptosis and growth inhibitory rates of U251 glioma cells, and thereby increase their sensitivity to DDP chemotherapy." @default.
- W2130942146 created "2016-06-24" @default.
- W2130942146 creator A5009191195 @default.
- W2130942146 creator A5059617187 @default.
- W2130942146 creator A5064488623 @default.
- W2130942146 creator A5078681240 @default.
- W2130942146 creator A5081344725 @default.
- W2130942146 date "2015-02-04" @default.
- W2130942146 modified "2023-09-27" @default.
- W2130942146 title "Influence of the MACC1 Gene on Sensitivity to Chemotherapy in Human U251 Glioblastoma Cells" @default.
- W2130942146 cites W1993869441 @default.
- W2130942146 cites W2006233465 @default.
- W2130942146 cites W2113696549 @default.
- W2130942146 doi "https://doi.org/10.7314/apjcp.2015.16.1.195" @default.
- W2130942146 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25640351" @default.
- W2130942146 hasPublicationYear "2015" @default.
- W2130942146 type Work @default.
- W2130942146 sameAs 2130942146 @default.
- W2130942146 citedByCount "15" @default.
- W2130942146 countsByYear W21309421462016 @default.
- W2130942146 countsByYear W21309421462017 @default.
- W2130942146 countsByYear W21309421462018 @default.
- W2130942146 countsByYear W21309421462019 @default.
- W2130942146 countsByYear W21309421462020 @default.
- W2130942146 countsByYear W21309421462021 @default.
- W2130942146 countsByYear W21309421462023 @default.
- W2130942146 crossrefType "journal-article" @default.
- W2130942146 hasAuthorship W2130942146A5009191195 @default.
- W2130942146 hasAuthorship W2130942146A5059617187 @default.
- W2130942146 hasAuthorship W2130942146A5064488623 @default.
- W2130942146 hasAuthorship W2130942146A5078681240 @default.
- W2130942146 hasAuthorship W2130942146A5081344725 @default.
- W2130942146 hasBestOaLocation W21309421461 @default.
- W2130942146 hasConcept C104317684 @default.
- W2130942146 hasConcept C105580179 @default.
- W2130942146 hasConcept C119056186 @default.
- W2130942146 hasConcept C126322002 @default.
- W2130942146 hasConcept C134018914 @default.
- W2130942146 hasConcept C153911025 @default.
- W2130942146 hasConcept C17077164 @default.
- W2130942146 hasConcept C185592680 @default.
- W2130942146 hasConcept C190283241 @default.
- W2130942146 hasConcept C2776694085 @default.
- W2130942146 hasConcept C2778227246 @default.
- W2130942146 hasConcept C2778239845 @default.
- W2130942146 hasConcept C2779707156 @default.
- W2130942146 hasConcept C2780783641 @default.
- W2130942146 hasConcept C502942594 @default.
- W2130942146 hasConcept C553184892 @default.
- W2130942146 hasConcept C55493867 @default.
- W2130942146 hasConcept C71924100 @default.
- W2130942146 hasConcept C85265743 @default.
- W2130942146 hasConcept C86803240 @default.
- W2130942146 hasConceptScore W2130942146C104317684 @default.
- W2130942146 hasConceptScore W2130942146C105580179 @default.
- W2130942146 hasConceptScore W2130942146C119056186 @default.
- W2130942146 hasConceptScore W2130942146C126322002 @default.
- W2130942146 hasConceptScore W2130942146C134018914 @default.
- W2130942146 hasConceptScore W2130942146C153911025 @default.
- W2130942146 hasConceptScore W2130942146C17077164 @default.
- W2130942146 hasConceptScore W2130942146C185592680 @default.
- W2130942146 hasConceptScore W2130942146C190283241 @default.
- W2130942146 hasConceptScore W2130942146C2776694085 @default.
- W2130942146 hasConceptScore W2130942146C2778227246 @default.
- W2130942146 hasConceptScore W2130942146C2778239845 @default.
- W2130942146 hasConceptScore W2130942146C2779707156 @default.
- W2130942146 hasConceptScore W2130942146C2780783641 @default.
- W2130942146 hasConceptScore W2130942146C502942594 @default.
- W2130942146 hasConceptScore W2130942146C553184892 @default.
- W2130942146 hasConceptScore W2130942146C55493867 @default.
- W2130942146 hasConceptScore W2130942146C71924100 @default.
- W2130942146 hasConceptScore W2130942146C85265743 @default.
- W2130942146 hasConceptScore W2130942146C86803240 @default.
- W2130942146 hasIssue "1" @default.
- W2130942146 hasLocation W21309421461 @default.
- W2130942146 hasLocation W21309421462 @default.
- W2130942146 hasOpenAccess W2130942146 @default.
- W2130942146 hasPrimaryLocation W21309421461 @default.
- W2130942146 hasRelatedWork W1977860891 @default.
- W2130942146 hasRelatedWork W2023053165 @default.
- W2130942146 hasRelatedWork W2144448045 @default.
- W2130942146 hasRelatedWork W2358507455 @default.
- W2130942146 hasRelatedWork W2369956623 @default.
- W2130942146 hasRelatedWork W2371090843 @default.
- W2130942146 hasRelatedWork W2371307295 @default.
- W2130942146 hasRelatedWork W2391804837 @default.
- W2130942146 hasRelatedWork W3028727730 @default.
- W2130942146 hasRelatedWork W3032388903 @default.
- W2130942146 hasVolume "16" @default.
- W2130942146 isParatext "false" @default.
- W2130942146 isRetracted "false" @default.
- W2130942146 magId "2130942146" @default.
- W2130942146 workType "article" @default.