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• W2130943949 abstract "Population-based epidemiological studies strongly implicate obstructive sleep apnoea (OSA) as an independent risk factor for cardiovascular morbidity and mortality [1–7]. Final proof of a causal relationship between OSA and premature cardiovascular disease, and the true strength of that relationship, will depend on the results of large, well-designed randomised controlled trials of OSA treatment, several of which are ongoing [8]. In the meantime there is considerable interest in the various mechanistic pathways whereby OSA might lead to increased cardiovascular disease/events. A clearer understanding of these pathways will probably have practical therapeutic implications for reducing cardiovascular risk in OSA populations in the future. Devices such as continuous positive airway pressure (CPAP) and mandibular repositioning devices are effective treatments for OSA, but the reality is that they are found to be unacceptable or are used infrequently by many patients with OSA, particularly those who are minimally symptomatic. Other treatments directed specifically at mitigating cardiovascular risk in such patients may be needed and this will require a clear understanding of the dominant mechanisms for increased cardiovascular disease and/or cardiovascular events in OSA.Systemic hypertension is the most important risk factor for cardiovascular disease. There is now strong evidence from randomised controlled trials of CPAP treatment of OSA that sleep apnoea is responsible for an increase in nocturnal and diurnal blood pressure, although to what extent OSA causes clinical hypertension is less certain. While early cross sectional data from community studies found a relatively robust independent association between OSA and prevalent hypertension [9–11], the results of longitudinal studies examining the role of OSA in the development of new hypertension have been less convincing. Some studies have shown an independent association between OSA and incident hypertension [12, 13], while others have not [ …" @default.
• W2130943949 created "2016-06-24" @default.
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• W2130943949 date "2014-09-30" @default.
• W2130943949 modified "2023-09-28" @default.
• W2130943949 title "Obstructive sleep apnoea and hypertension: the ESADA study" @default.
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• W2130943949 doi "https://doi.org/10.1183/09031936.00129614" @default.
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