Matches in SemOpenAlex for { <https://semopenalex.org/work/W2130962254> ?p ?o ?g. }
- W2130962254 endingPage "e13741" @default.
- W2130962254 startingPage "e13741" @default.
- W2130962254 abstract "The blood-brain barrier (BBB) maintains brain homeostasis and limits the entry of toxins and pathogens into the brain. Despite its importance, little is known about the molecular mechanisms regulating the development and function of this crucial barrier. In this study we have developed methods to highly purify and gene profile endothelial cells from different tissues, and by comparing the transcriptional profile of brain endothelial cells with those purified from the liver and lung, we have generated a comprehensive resource of transcripts that are enriched in the BBB forming endothelial cells of the brain. Through this comparison we have identified novel tight junction proteins, transporters, metabolic enzymes, signaling components, and unknown transcripts whose expression is enriched in central nervous system (CNS) endothelial cells. This analysis has identified that RXRalpha signaling cascade is specifically enriched at the BBB, implicating this pathway in regulating this vital barrier. This dataset provides a resource for understanding CNS endothelial cells and their interaction with neural and hematogenous cells." @default.
- W2130962254 created "2016-06-24" @default.
- W2130962254 creator A5027970945 @default.
- W2130962254 creator A5032562567 @default.
- W2130962254 creator A5061101783 @default.
- W2130962254 creator A5085315691 @default.
- W2130962254 creator A5086104464 @default.
- W2130962254 creator A5088055614 @default.
- W2130962254 date "2010-10-29" @default.
- W2130962254 modified "2023-10-14" @default.
- W2130962254 title "The Mouse Blood-Brain Barrier Transcriptome: A New Resource for Understanding the Development and Function of Brain Endothelial Cells" @default.
- W2130962254 cites W128151115 @default.
- W2130962254 cites W1588361932 @default.
- W2130962254 cites W1965681567 @default.
- W2130962254 cites W1969460388 @default.
- W2130962254 cites W1972326404 @default.
- W2130962254 cites W1973418567 @default.
- W2130962254 cites W1973544766 @default.
- W2130962254 cites W1973763077 @default.
- W2130962254 cites W1976177535 @default.
- W2130962254 cites W1977989414 @default.
- W2130962254 cites W1980085014 @default.
- W2130962254 cites W1987589505 @default.
- W2130962254 cites W1990990311 @default.
- W2130962254 cites W1992758695 @default.
- W2130962254 cites W2000441131 @default.
- W2130962254 cites W2004381763 @default.
- W2130962254 cites W2005447528 @default.
- W2130962254 cites W2007739207 @default.
- W2130962254 cites W2015541518 @default.
- W2130962254 cites W2020554150 @default.
- W2130962254 cites W2022219701 @default.
- W2130962254 cites W2026122111 @default.
- W2130962254 cites W2027235566 @default.
- W2130962254 cites W2027654614 @default.
- W2130962254 cites W2032112615 @default.
- W2130962254 cites W2036191066 @default.
- W2130962254 cites W2036308278 @default.
- W2130962254 cites W2048829586 @default.
- W2130962254 cites W2050589760 @default.
- W2130962254 cites W2054681185 @default.
- W2130962254 cites W2061724183 @default.
- W2130962254 cites W2075177338 @default.
- W2130962254 cites W2081263150 @default.
- W2130962254 cites W2081454918 @default.
- W2130962254 cites W2083092470 @default.
- W2130962254 cites W2083470832 @default.
- W2130962254 cites W2085146964 @default.
- W2130962254 cites W2091805482 @default.
- W2130962254 cites W2092641793 @default.
- W2130962254 cites W2104567497 @default.
- W2130962254 cites W2104839879 @default.
- W2130962254 cites W2108162507 @default.
- W2130962254 cites W2109975931 @default.
- W2130962254 cites W2114409905 @default.
- W2130962254 cites W2115167653 @default.
- W2130962254 cites W2118309500 @default.
- W2130962254 cites W2124940469 @default.
- W2130962254 cites W2147977611 @default.
- W2130962254 cites W2152353759 @default.
- W2130962254 cites W2152877944 @default.
- W2130962254 cites W2155510294 @default.
- W2130962254 cites W2155957079 @default.
- W2130962254 cites W2162709471 @default.
- W2130962254 cites W2163830368 @default.
- W2130962254 cites W2245482469 @default.
- W2130962254 cites W2912349604 @default.
- W2130962254 doi "https://doi.org/10.1371/journal.pone.0013741" @default.
- W2130962254 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2966423" @default.
- W2130962254 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21060791" @default.
- W2130962254 hasPublicationYear "2010" @default.
- W2130962254 type Work @default.
- W2130962254 sameAs 2130962254 @default.
- W2130962254 citedByCount "463" @default.
- W2130962254 countsByYear W21309622542012 @default.
- W2130962254 countsByYear W21309622542013 @default.
- W2130962254 countsByYear W21309622542014 @default.
- W2130962254 countsByYear W21309622542015 @default.
- W2130962254 countsByYear W21309622542016 @default.
- W2130962254 countsByYear W21309622542017 @default.
- W2130962254 countsByYear W21309622542018 @default.
- W2130962254 countsByYear W21309622542019 @default.
- W2130962254 countsByYear W21309622542020 @default.
- W2130962254 countsByYear W21309622542021 @default.
- W2130962254 countsByYear W21309622542022 @default.
- W2130962254 countsByYear W21309622542023 @default.
- W2130962254 crossrefType "journal-article" @default.
- W2130962254 hasAuthorship W2130962254A5027970945 @default.
- W2130962254 hasAuthorship W2130962254A5032562567 @default.
- W2130962254 hasAuthorship W2130962254A5061101783 @default.
- W2130962254 hasAuthorship W2130962254A5085315691 @default.
- W2130962254 hasAuthorship W2130962254A5086104464 @default.
- W2130962254 hasAuthorship W2130962254A5088055614 @default.
- W2130962254 hasBestOaLocation W21309622541 @default.
- W2130962254 hasConcept C104317684 @default.
- W2130962254 hasConcept C123012128 @default.
- W2130962254 hasConcept C14036430 @default.
- W2130962254 hasConcept C150194340 @default.