FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2130975304> ?p ?o ?g. }

• W2130975304 endingPage "16657" @default.
• W2130975304 startingPage "16647" @default.
• W2130975304 abstract "Crystalline nanoparticles of cellulose exhibit attractive properties as nanoscale carriers for bioactive molecules in nanobiotechnology and nanomedicine. For applications in imaging and drug delivery, surface charge is one of the most important factors affecting the performance of nanocarriers. However, current methods of preparation offer little flexibility for controlling the surface charge of cellulose nanocrystals, leading to compromised colloidal stability under physiological conditions. We report a synthesis method that results in nanocrystals with remarkably high carboxyl content (6.6 mmol g(-1)) and offers continuous control over surface charge without any adjustment to the reaction conditions. Six fractions of nanocrystals with various surface carboxyl contents were synthesized from a single sample of softwood pulp with carboxyl contents varying from 6.6 to 1.7 mmol g(-1) and were fully characterized. The proposed method resulted in highly stable colloidal nanocrystals that did not aggregate when exposed to high salt concentrations or serum-containing media. Interactions of these fractions with four different tissue cell lines were investigated over a wide range of concentrations (50-300 μg mL(-1)). Darkfield hyperspectral imaging and confocal microscopy confirmed the uptake of nanocrystals by selected cell lines without any evidence of membrane damage or change in cell density; however a charge-dependent decrease in mitochondrial activity was observed for charge contents higher than 3.9 mmol g(-1). A high surface carboxyl content allowed for facile conjugation of fluorophores to the nanocrystals without compromising colloidal stability. The cellular uptake of fluoresceinamine-conjugated nanocrystals exhibited a time-dose dependent relationship and increased significantly with doubling of the surface charge." @default.
• W2130975304 created "2016-06-24" @default.
• W2130975304 creator A5039369992 @default.
• W2130975304 creator A5046135600 @default.
• W2130975304 creator A5056056148 @default.
• W2130975304 creator A5056899042 @default.
• W2130975304 creator A5081770881 @default.
• W2130975304 date "2015-01-01" @default.
• W2130975304 modified "2023-10-16" @default.
• W2130975304 title "Cellulose nanocrystals with tunable surface charge for nanomedicine" @default.
• W2130975304 cites W1970329642 @default.
• W2130975304 cites W1970848679 @default.
• W2130975304 cites W1971748223 @default.
• W2130975304 cites W1973315409 @default.
• W2130975304 cites W1974218815 @default.
• W2130975304 cites W1981816806 @default.
• W2130975304 cites W1992941976 @default.
• W2130975304 cites W1996442036 @default.
• W2130975304 cites W1998033723 @default.
• W2130975304 cites W2008312847 @default.
• W2130975304 cites W2015497529 @default.
• W2130975304 cites W2024212563 @default.
• W2130975304 cites W2026463006 @default.
• W2130975304 cites W2027876233 @default.
• W2130975304 cites W2036735781 @default.
• W2130975304 cites W2059231520 @default.
• W2130975304 cites W2060001912 @default.
• W2130975304 cites W2066238972 @default.
• W2130975304 cites W2070975562 @default.
• W2130975304 cites W2076115726 @default.
• W2130975304 cites W2084049539 @default.
• W2130975304 cites W2084741099 @default.
• W2130975304 cites W2089134953 @default.
• W2130975304 cites W2089668979 @default.
• W2130975304 cites W2091099221 @default.
• W2130975304 cites W2095460557 @default.
• W2130975304 cites W2096991082 @default.
• W2130975304 cites W2104558356 @default.
• W2130975304 cites W2117135512 @default.
• W2130975304 cites W2140652395 @default.
• W2130975304 cites W2149965488 @default.
• W2130975304 cites W2318683722 @default.
• W2130975304 doi "https://doi.org/10.1039/c5nr02506k" @default.
• W2130975304 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26154822" @default.
• W2130975304 hasPublicationYear "2015" @default.
• W2130975304 type Work @default.
• W2130975304 sameAs 2130975304 @default.
• W2130975304 citedByCount "89" @default.
• W2130975304 countsByYear W21309753042016 @default.
• W2130975304 countsByYear W21309753042017 @default.
• W2130975304 countsByYear W21309753042018 @default.
• W2130975304 countsByYear W21309753042019 @default.
• W2130975304 countsByYear W21309753042020 @default.
• W2130975304 countsByYear W21309753042021 @default.
• W2130975304 countsByYear W21309753042022 @default.
• W2130975304 countsByYear W21309753042023 @default.
• W2130975304 crossrefType "journal-article" @default.
• W2130975304 hasAuthorship W2130975304A5039369992 @default.
• W2130975304 hasAuthorship W2130975304A5046135600 @default.
• W2130975304 hasAuthorship W2130975304A5056056148 @default.
• W2130975304 hasAuthorship W2130975304A5056899042 @default.
• W2130975304 hasAuthorship W2130975304A5081770881 @default.
• W2130975304 hasBestOaLocation W21309753041 @default.
• W2130975304 hasConcept C127413603 @default.
• W2130975304 hasConcept C147789679 @default.
• W2130975304 hasConcept C15083742 @default.
• W2130975304 hasConcept C155672457 @default.
• W2130975304 hasConcept C171250308 @default.
• W2130975304 hasConcept C175854130 @default.
• W2130975304 hasConcept C18150654 @default.
• W2130975304 hasConcept C185592680 @default.
• W2130975304 hasConcept C192562407 @default.
• W2130975304 hasConcept C204399865 @default.
• W2130975304 hasConcept C26926545 @default.
• W2130975304 hasConcept C2779251873 @default.
• W2130975304 hasConcept C2779820397 @default.
• W2130975304 hasConcept C2780358262 @default.
• W2130975304 hasConcept C42360764 @default.
• W2130975304 hasConcept C59789625 @default.
• W2130975304 hasConceptScore W2130975304C127413603 @default.
• W2130975304 hasConceptScore W2130975304C147789679 @default.
• W2130975304 hasConceptScore W2130975304C15083742 @default.
• W2130975304 hasConceptScore W2130975304C155672457 @default.
• W2130975304 hasConceptScore W2130975304C171250308 @default.
• W2130975304 hasConceptScore W2130975304C175854130 @default.
• W2130975304 hasConceptScore W2130975304C18150654 @default.
• W2130975304 hasConceptScore W2130975304C185592680 @default.
• W2130975304 hasConceptScore W2130975304C192562407 @default.
• W2130975304 hasConceptScore W2130975304C204399865 @default.
• W2130975304 hasConceptScore W2130975304C26926545 @default.
• W2130975304 hasConceptScore W2130975304C2779251873 @default.
• W2130975304 hasConceptScore W2130975304C2779820397 @default.
• W2130975304 hasConceptScore W2130975304C2780358262 @default.
• W2130975304 hasConceptScore W2130975304C42360764 @default.
• W2130975304 hasConceptScore W2130975304C59789625 @default.
• W2130975304 hasIssue "40" @default.
• W2130975304 hasLocation W21309753041 @default.
• W2130975304 hasLocation W21309753042 @default.

• next