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• W2131014647 abstract "ABSTRACT The induction of proinflammatory cytokines such as gamma interferon (IFN-γ) and tumor necrosis factor alpha is crucial for the early control of bacterial infections. Since interleukin-18 (IL-18) acts as a potent inducer of IFN-γ, it might play an important role in the induction of a protective immune response in listeriosis. We used a murine model of systemic Listeria monocytogenes infection to study the immune response to these intracellular bacteria in the absence of IL-18. For this purpose, IL-18-deficient mice and mice treated with anti-IL-18 neutralizing antibody were infected with L. monocytogenes , and their innate and adaptive immune responses were compared to those of control mice. Unexpectedly, we found that mice deficient in IL-18 were partially resistant to primary infection with L. monocytogenes . At day 3 after infection, the numbers of listeriae in the livers and spleens of control mice were up to 500 times higher than those in IL-18-deficient or anti-IL-18 antibody-treated mice. In addition, the level of proinflammatory cytokines was markedly reduced in IL-18-deficient mice. Enhanced resistance to L. monocytogenes infection in IL-18-deficient mice was accompanied by increased numbers of leukocytes and reduced apoptosis in the spleen 48 to 72 h after infection. In contrast, control and IL-18-deficient mice showed no significant differences in their abilities to mount a protective L. monocytogenes -specific T-cell response." @default.
• W2131014647 created "2016-06-24" @default.
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• W2131014647 date "2008-09-01" @default.
• W2131014647 modified "2023-09-27" @default.
• W2131014647 title "Decreased Susceptibility of Mice to Infection with <i>Listeria monocytogenes</i> in the Absence of Interleukin-18" @default.
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• W2131014647 doi "https://doi.org/10.1128/iai.01651-07" @default.
• W2131014647 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2519415" @default.
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