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- W2131021979 abstract "Summary Malaria parasites grow within erythrocytes, but are also free in host plasma between cycles of asexual replication. As a result, the parasite is exposed to fluctuating levels of N a + and K + , ions assumed to serve important roles for the human pathogen, P lasmodium falciparum . We examined these assumptions and the parasite's ionic requirements by establishing continuous culture in novel sucrose‐based media. With sucrose as the primary osmoticant and K + and C l − as the main extracellular ions, we obtained parasite growth and propagation at rates indistinguishable from those in physiological media. These conditions abolish long‐known increases in intracellular N a + via parasite‐induced channels, excluding a requirement for erythrocyte cation remodelling. We also dissected N a + , K + and C l − requirements and found that unexpectedly low concentrations of each ion meet the parasite's demands. Surprisingly, growth was not adversely affected by up to 148 mM K + , suggesting that low extracellular K + is not an essential trigger for erythrocyte invasion. At the same time, merozoite egress and invasion required a threshold ionic strength, suggesting critical electrostatic interactions between macromolecules at these stages. These findings provide insights into transmembrane signalling in malaria and reveal fundamental differences between host and parasite ionic requirements." @default.
- W2131021979 created "2016-06-24" @default.
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- W2131021979 date "2013-02-26" @default.
- W2131021979 modified "2023-10-16" @default.
- W2131021979 title "Malaria parasites tolerate a broad range of ionic environments and do not require host cation remodelling" @default.
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- W2131021979 doi "https://doi.org/10.1111/mmi.12159" @default.
- W2131021979 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3608822" @default.
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