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- W2131042010 abstract "RNA performs a diverse array of important functions across all cellular life. These functions include important roles in translation, building translational machinery and maturing messenger RNA. More recent discoveries include the miRNAs and bacterial sRNAs that regulate gene expression, the thermosensors, riboswitches and other cis-regulatory elements that help prokaryotes sense their environment and eukaryotic piRNAs that suppress transposition. However, there can be a long period between the initial discovery of a RNA and determining its function. We present a bioinformatic approach to characterize RNA motifs, which are critical components of many RNA structure-function relationships. These motifs can, in some instances, provide researchers with functional hypotheses for uncharacterized RNAs. Moreover, we introduce a new profile-based database of RNA motifs--RMfam--and illustrate some applications for investigating the evolution and functional characterization of RNA. All the data and scripts associated with this work are available from: https://github.com/ppgardne/RMfam." @default.
- W2131042010 created "2016-06-24" @default.
- W2131042010 creator A5067459027 @default.
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- W2131042010 date "2014-12-17" @default.
- W2131042010 modified "2023-10-13" @default.
- W2131042010 title "Annotating RNA motifs in sequences and alignments" @default.
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- W2131042010 doi "https://doi.org/10.1093/nar/gku1327" @default.
- W2131042010 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4333381" @default.
- W2131042010 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25520192" @default.
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